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ABCB9 Antibody

  • 中文名稱：
    ABCB9兔多克隆抗體
  • 貨號：
    CSB-PA001055GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ABCB9
  • 別名：
    ABCB9 antibody; KIAA1520ATP-binding cassette sub-family B member 9 antibody; ATP-binding cassette transporter 9 antibody; ABC transporter 9 protein antibody; hABCB9 antibody; TAP-like protein antibody; TAPL antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ABCB9
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
  • 基因功能參考文獻：
    1. The structure of the unique domain of TAPL, is reported. PMID: 24013930
    2. LAMP proteins retain TAPL on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles. PMID: 22641697
    3. These results suggest that TAPL may be localized to the microdomains (lipid rafts) of lysosomal membranes enriched in cholesterol. PMID: 21212514
    4. By dissecting ABCB9, distinct functions were assigned to the core complex and the extra N-terminal transmembrane domain. PMID: 20377823
    5. is part of the peptide-loading complex in the classic route of antigen processing via major histocompatibility complex class I molecules PMID: 15863492
    6. These findings suggest that the transport activity of hTAPL is important for conferring high valinomycin-sensitive phenotype to yeast. PMID: 16554024
    7. the TAPL-specific translocation of peptides into isolated lysosomes strictly requires ATP hydrolysis PMID: 17977821
    8. The ATP-binding of TAPL required Mg(2+), and was observed at neutral pH. Chemical cross-linking experiments suggested that TAPL forms a homodimer in the membrane and under the solubilized conditions. PMID: 18175933
    9. analysis of lipid activation of the lysosomal transport complex ABCB9 PMID: 18434309
    10. These results suggest that the sorting signal for lysosomes is present within the amino-terminal transmembrane domain (Met(1)-Arg(141)) of the TAPL molecule. PMID: 18952056

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  • 亞細胞定位：
    Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3.A.1.209) subfamily
  • 組織特異性：
    Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 50

    OMIM: 605453

    KEGG: hsa:23457

    STRING: 9606.ENSP00000280560

    UniGene: Hs.511951