Rat plasminogen activator inhibitor 1,PAI1 ELISA Kit
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中文名稱:大鼠纖溶酶原激活物抑制因子1(PAI1)酶聯(lián)免疫試劑盒
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貨號:CSB-E07948r
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規(guī)格:96T/48T
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價格:¥3900/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:血管纖溶酶原激活物抑制劑1(SERPINE1)是一種主要存在于血液中的蛋白質(zhì),其主要功能是抑制纖溶過程。它在維持血栓穩(wěn)定和避免出血方面起著重要作用。此外,它還參與許多生理過程,如血管生成、細(xì)胞遷移、組織修復(fù)和炎癥反應(yīng)等。SERPINE1的含量在炎癥、心血管疾病、腫瘤等疾病的發(fā)生和發(fā)展中具有重要意義。華美生物所提供的Rat plasminogen activator inhibitor 1,PAI1 ELISA Kit屬于ELISA檢測試劑盒,采用雙抗夾心法定量檢測大鼠血清、血漿、組織勻漿樣本中的SERPINE1,其靈敏度為19.5 pg/ml,檢測范圍為78 pg/ml-5000 pg/ml。
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別名:Serpine1 ELISA Kit; Pai1 ELISA Kit; Planh1 ELISA Kit; Plasminogen activator inhibitor 1 ELISA Kit; PAI ELISA Kit; PAI-1 ELISA Kit; Endothelial plasminogen activator inhibitor ELISA Kit; Serpin E1 ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Rattus norvegicus (Rat)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:78 pg/ml-5000 pg/ml
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靈敏度:19.5 pg/ml
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Cell Biology
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- Dehydroepiandrosterone (DHEA) Improves the Metabolic and Haemostatic Disturbances in Rats with Male Hypogonadism SM Safwat,Multidisciplinary Digital Publishing Institute,2022
- BAY11-7082 inhibits the expression of tissue factor and plasminogen activator inhibitor-1 in type-II alveolar epithelial cells following TNF-α stimulation via the NF-κB pathway Y Cheng,Experimental and Therapeutic Medicine,2021
- Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic … I Margaritis,Journal of Biological Research-Thessaloniki,2020
- Both UFH and NAH alleviate shedding of endothelial glycocalyx and coagulopathy in LPS Huang X, et al,Experimental and Therapeutic Medicine,2019
- Pre-Diabetes Induces Ultrastructural Alterations in the Large Blood Vessel Aorta in Rats Abbas O El-Karib,International Journal of Morphology,2019
- Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance Dallak M.et al,Arch Physiol Biochem,2018
- Swimming, but not vitamin E, ameliorates prothrombotic state and hypofibrinolysis in a rat model of nonalcoholic fatty liver disease Sakr HF.et al,J Basic Clin Physiol Pharmacol,2017
- Signaling by TGF-betas in tubule cultures of adult rat testis Chan KH.et al,Am J Transl Res.,2017
- Anti-Hypertensive Effects of Black Raspberry (Rubus occidentalis) in Spontaneously Hypertensive Rats Lee J H.et al,Journal of the Korean Society of Food Science and Nutrition,2015
- Effects of warfarin and l-carnitine on hemostatic function and oxidative stress in streptozotocin-induced diabetic rats Elgendy AA et al,J Physiol Biochem,2014
產(chǎn)品評價
樣品類型:血漿(抗凝劑) edta
樣品信息:大鼠
稀釋比:沒有稀釋
產(chǎn)品評價: 我用RAT PAI-1 elisa試劑盒檢測大鼠血漿樣本,操作簡便快捷,靈敏度較高,數(shù)據(jù)較穩(wěn)定。樣品不稀釋時,對照組和處理組OD均在標(biāo)曲范圍。
By 杜老師
相關(guān)產(chǎn)品
問答及客戶評論
Is the kit of tPA(tissue plasminogen activator) cab be used for kidney rat lysat?
The research is about preeclampsia and damage to the kidney in pregnancy. We have a material that raises the level of tPA. tPA is anti coagulation protien that we think is involved in antiapoptosis.
We injected this material to pregnancy rats with preeclampsia, and we took out the kidneys. Now we want to test the level of tPa and its inhibitor PAI1, in this kidneys.
Please email me the product number?
We have this kit for you: CSB-E07917r,Rat Tissue-type Plasiminogen Actilyse,t-PA ELISA Kit.
Additionally, if you want to test PAI1,we have this kit available for you: CSB-E07948r,Rat plasminogen activator inhibitor 1,PAI1 ELISA Kit.
I will send you the kit manuals by email.
Regarding to the 2 cases you mentioned, sorry we did not validate before.We suggest you do a pretest first.
If further questions,pls let us know.
靶點詳情
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最新研究進(jìn)展:SERPINE1是一種血液凝血和纖溶系統(tǒng)中的蛋白質(zhì),最新研究發(fā)現(xiàn)它在調(diào)節(jié)炎癥、免疫和血管生成等生物學(xué)過程中發(fā)揮著重要作用。
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功能:Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis.
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基因功能參考文獻(xiàn):
- PAI-1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease. PMID: 28722352
- PAI-1 is implicated in the pathophysiology of depression. PMID: 27456456
- Our results demonstrate the antifibrotic effect of PTX on radiation-induced lung fibrosis and its effect on modulation of PKA and PAI-1 expression as possible antifibrotic mechanisms. PMID: 28337441
- Paclitaxel at low non-cytotoxic doses ameliorates renal fibrosis by inhibiting multiple steps in the TGF-beta1-induced PAI-1 signaling including Smads and mitogen-activated protein kinases. PMID: 26869361
- Aldosterone at different concentrations exerts synergistic effect with TGF-beta1 to increase PAI-1 expression in hepatic stellate cells PMID: 26617694
- inhibition of ERK1/2 activation has no therapeutic effect on kidney fibrosis in SNx possibly due to increased compensatory activation of the p38 and JNK signalling pathways with subsequent upregulation of PAI-1. PMID: 26415098
- These results suggest the critical physiological role of TRL4-Fyn interaction in the modulation of PAI-1-tPA axis in astrocytes during neuroinflammatory responses such as ischemia/reperfusion injuries. PMID: 25106729
- these results suggested that TGF-beta1 and Serpine 1 overexpression might play an important role in DVT formation and have predictive values. PMID: 26535698
- PAI-1 contributes to the regulation of the inflammatory response in alveolar macrophages. PMID: 25342286
- Neurite extension effects of valproic acid are mediated by modulating the tPA/plasminogen activator inhibitor (PAI)-1 system. PMID: 23378038
- Together, because CPAI blocks both proteolytic and nonproteolytic tPA neurotoxicity, it is a promising therapeutics of neonatal HI injury either with or without infection. PMID: 22556277
- PAI-1 promotes the proliferation, transforming into myofibroblasts, collagen synthesis, and inhibits apoptosis of pulmonary fibroblasts by activating Ca(2+), ERK and AKT signaling pathway. PMID: 23021499
- adhesion scores, PAI-1 activity in peritoneal lavage fluid, and PAI-1 mRNA levels in peritoneal mesothelium were significantly greater in the open surgery group than the control and laparoscopic surgery groups PMID: 23218127
- This study supports that a preceding progesterone-enriched milieu prevented the enhanced prothrombotic risk induced by a fructose-rich diet-elicited high PAI-1 production. PMID: 23016136
- down-regulation of PAI-1 and MMP-9 might contribute to abnormal programming of renal growth in rats exposed to postnatal early overnutrition PMID: 21752621
- The data demonstrate that PAI-1 siRNA inhibits alveolitis and pulmonary fibrosis in bleomycin-treated rats via inhibiting the proliferation and promoting the apoptosis of fibroblasts. PMID: 22659625
- mRNA, protein and activity of matrix metalloproteinase (MMP)-2 and MMP-9 and mRNA of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were quantified in abdominal aorta (AA) and femoral artery (FA). PMID: 22071631
- Hydrocortisone up-regulates PAI-1 expression in a tissue-specific manner along with down-regulation of tPA activity in both normal and inflammatory conditions. PMID: 21412817
- The activity of tissue plasminogen activator peaks transiently and then decreases in cortex and striatum along with delayed induction of PAI-1 in the inflammatory stage after reperfusion injury. PMID: 21193004
- Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue stimulation. PMID: 21596853
- PAI-1 derived from the neurovascular unit and peripheral vascular system participates as a positive regulator of the blood-brain barrier in facilitating the barrier function of the endothelial tight junctions. PMID: 21036181
- Erigeron breviscapus injection can inhibit the expression of TNF-alpha and PAI-1, and increase the expression of tPA in rats with acute myocardial infarction. PMID: 21355198
- PAI-1 may play a protective role against cardiovascular disease in diabetes PMID: 20538356
- Expression of u-PA/PAI-1 mRNA and protein increased during the early stage of hyperoxic exposure and decreased during the middle and late stage. PMID: 19099788
- The results suggest that SHP inhibits PAI-1 expression in VSMCs through the suppression of TGF-beta/Smad3 and AP-1 activity. PMID: 19887897
- High glucose decreased the expressions of tPA and uPA, and increased PAI1. Losartan could partly reverse partly this expression. PMID: 17953365
- Dahuang Zhechong Pill can down-regulate the expressions of TIMP-1 and PAI-1 mRNAs in renal tissues of rats with focal segmental glomerulosclerosis. PMID: 18471418
- Inactivation of PAI-1 speeds lysis of a platelet-rich clot in rat mesenteric arterioles. Active PAI-1 participates in arteriolar microcirculation resistance to thrombolysis and its inactivation may shorten ischemic periods after microvascular obstruction. PMID: 11776323
- The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-betaI and -delta. PMID: 12105191
- pathways of regulation of PAI1 induction and secretion by growth factors bFGF and PDGF in smooth muscle cells PMID: 12192306
- Data show that recovery from obstruction-induced renal fibrosis was correlated with diminished expression of TGF-beta, collagen IV, and plasminogen activator inhibitor-1. PMID: 12365557
- HIF1a and hypoxia response elements mediate the induction of PAI-1 gene expression by insulin via the PI3K/PKB pathway in primary rat hepatocytes. PMID: 12393531
- possible role as the neurotrophic factor PMID: 12491782
- Expression of functionally active PN-1 has been examined in vitro in rat aortic smooth muscle cells and in vivo in rat arterial media and its regulation in hypertensive rats. PMID: 12524238
- Northern analysis confirmed upregulation of PAI-1, P2X4, and P15INK4B in cultured alveolar epithelial type I cells (AT1); in whole lung, all three proteins were detected in alveolar epithelium in a location consistent with expression in AT1 cells PMID: 12600825
- hypoxia-dependent plasminogen activator inhibitor 1 expression is regulated by MAP kinases PMID: 12669121
- In cells expressing RacG12V, ROS production was increased and PAI-1 mRNA levels as well as HIF-alpha nuclear presence were reduced under normoxia and hypoxia; whereas expression of RacT17N resulted in decreased ROS production and opposite effects. PMID: 12719791
- Enhanced expression of clock genes may increase PAI-1 expression in concert with activated renin-angiotensin system in SHR heart PMID: 12777947
- after transient focal cerebral ischemia, there are time dependent changes in PAI-1 expression PMID: 14512838
- cellular carbonyl stress may stimulate PAI-1 synthesis in and release from adipose tissues through ROS formation PMID: 14610081
- Pai1 expression is required for epithelial cell migration in in vitro wound healing. PMID: 15174100
- PAI-1 and TGF-beta 1 in carotid glomus and autonomic ganglia were significantly increased (P < 0.01) in hypertensive rats PMID: 15201552
- Altered expression of Pai-1 in diabetic nephropathy was associated with mesangial expansion. PMID: 15322501
- Regression of glomerulosclerosis was linked to decreased tissue inhibitor of metalloproteinase-1 and plasminogen activator inhibitor-1. PMID: 15728787
- Cardiac PAI-1 gene expression regulation is mediated through c-Jun NH2-terminal kinase activation. PMID: 15808835
- the essential requirement of MAPK/AP-1 activation for TGF-beta1-induced PAI-1 expression is unique to rat mesangial cells PMID: 16105028
- A dual role for PAI-1 in epithelial cell wound healing, both as a soluble inhibitor of proteolysis and also as a matrix-bound regulator of cell migration, is proposed. PMID: 17071586
- This study indicate that aldosterone can increase PAI-1 mRNA and protein expression by cultured mesangial cells alone, which is independent of aldosterone-induced increases in TGF-beta(1) expression and cellular reactive oxygen species. PMID: 17394767
- Renin induces ERK1/2 activation. Renin-activated pathway triggers cell proliferation along with TGF-beta1 and plasminogen activator inhibitor-1 gene expression. PMID: 17396111
- PAI-1 plays a role in the occurrence of liver failure after excessive hepatectomy via accelerated maturation of pro-uPA and fibrinolytic factors. PMID: 17655862
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亞細(xì)胞定位:Secreted.
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蛋白家族:Serpin family
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