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中文名稱:大鼠8羥基脫氧鳥苷(8-OHdG)酶聯(lián)免疫試劑盒
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貨號:CSB-E10526r
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規(guī)格:96T/48T
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價格:¥3900/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:8-OHdG,也稱為 8-羥基脫氧鳥苷,是體內(nèi)氧化應激的標志物。它是一種生物標志物,可用于評估氧化損傷的水平和識別潛在的健康問題。 8-OHdG 已被發(fā)現(xiàn)在患有某些疾?。ㄈ绨┌Y、糖尿病、心血管疾病和神經(jīng)退行性疾?。┑膫€體中升高。此外,它還與衰老和空氣污染等環(huán)境壓力因素有關(guān)。研究表明,測量 8-OHdG 水平可以幫助診斷疾病狀態(tài)和監(jiān)測治療效果。因此,它是臨床醫(yī)學中評估患者氧化應激的重要工具。華美生物所提供的Rat 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit屬于ELISA檢測試劑盒,采用雙抗夾心法定量檢測大鼠血清、血漿、細胞培養(yǎng)上清、組織勻漿樣本中的8-OHdG,其靈敏度為華美生物所提供的0.078 ng/mL,檢測范圍為0.312 ng/mL-20 ng/mL。
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縮寫:8-OHdG
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種屬:Rattus norvegicus (Rat)
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樣本類型:serum, plasma, cell culture supernates, tissue homogenates
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檢測范圍:0.312 ng/mL-20 ng/mL
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靈敏度:0.078 ng/mL
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Cell Biology
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of rat 8-OHdG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 95 Range % 88-98 1:2 Average % 96 Range % 91-102 1:4 Average % 90 Range % 85-96 1:8 Average % 96 Range % 88-99 -
回收率:
The recovery of rat 8-OHdG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 102 98-107 EDTA plasma (n=4) 96 90-102 -
標準曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. ng/ml OD1 OD2 Average Corrected 20 1.890 1.780 1.835 1.682 10 1.198 1.128 1.163 1.010 5 0.756 0.726 0.741 0.588 2.5 0.525 0.495 0.510 0.357 1.25 0.321 0.318 0.320 0.167 0.625 0.272 0.262 0.267 0.114 0.312 0.213 0.209 0.211 0.058 0 0.154 0.152 0.153 -
數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻
- Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair Y Xiao,Nano-micro letters,2024
- Edible wild plants, chicory and purslane, alleviated diabetic testicular dysfunction, and insulin resistance via suppression 8OHdg and oxidative stress in rats EA Saad,PloS one,2024
- Mechanistic aspects of ameliorative effects of Eicosapentanoic acid ethyl ester on methotrexate-evoked testiculopathy in rats NAT Abbas,NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,2024
- Esculetin and Fucoidan Attenuate Autophagy and Apoptosis Induced by Zinc Oxide Nanoparticles through Modulating Reactive Astrocyte and Proinflammatory Cytokines in the Rat Brain WJ Song,Toxics,2023
- Anti-radiation effect of MRN-100: a hydro-ferrate fluid, in vivo Y Xue,Journal of radiation research,2024
- Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: Crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling pathways RM Salama,International immunopharmacology,2023
- Neuroprotective effect of peanut against oxidative stress in streptozotocin-induced diabetic rats NH Mohamed,Egyptian Journal of Basic and Applied Sciences,2022
- Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats XC Han,Medical Gas Research,2022
- The Effect of Metformin in Diabetic and Non-Diabetic Rats with Experimentally-Induced Chronic Kidney Disease MA Za'abi,Biomolecules,2021
- Graphene oxide induces dose?dependent lung injury in rats by regulating autophagy Mingke Qiu,Experimental and Therapeutic Medicine,2021
- β-Sitosterol attenuates liver injury in a rat model of chronic alcohol intake Z Chen,Archives of Pharmacal Research,2020
- Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats Ni XX,Cell Mol Neurobiol,2020
- Resveratrol improves left ventricular remodeling in chronic kidney disease via Sirt1-mediated regulation of FoxO1 activity and MnSOD expression Li P, et al,Biofactors,2019
- Isoorientin plays an important role in alleviating Cadmium-induced DNA damage and G0/G1 cell cycle arrest Shihao Chen, et al,Ecotoxicology and Environmental Safety,2019
- Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity Aladaileh SH, et al,Biomolecules,2019
- Amelioration of fenitrothion induced oxidative DNA damage and inactivation of caspase-3 in the brain and spleen tissues of male rats by N-acetylcysteine Rasha T. Alam,Life Sciences,2019
- The beneficial effect of α-tocopherol succinate supplementation on DNA oxidation induced by intensive exercise training Hossein TaheriChadorneshin, et al,Sport Sciences for Health,2018
- Aplysin Protects Against Alcohol┸\Induced Liver Injury Via Alleviating Oxidative Damage and Modulating Endogenous Apoptosis┸\Related Genes Expression in Rats Na Ge.et al,Journal of Food Science,2018
- PM2.5 induces male reproductive toxicity via mitochondrial dysfunction, DNA damage and RIPK1 mediated apoptotic signaling pathway Jin Zhang.et al,Science of The Total Environment,2018
- The Ameliorative Potential of Dexmedetomidine and Benincasa Cerifera Extract in Renal Ischemia/Reperfusion Injury in a Streptozotocin-Induced Diabetic Model Gehan A Hegazy.et al,Biomedical and Pharmacology,2018
- Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by inhibiting TGF-B signaling pathway activation in Type 2 Diabetic Rats Biyu Hou.et al,/,/
- Inhibition of Rac1 ameliorates neuronal oxidative stress damage via reducing Bcl-2/Rac1 complex formation in mitochondria through PI3K/Akt/mTOR Pan Y.et al,Exp Neurol,2017
- Nandrolone administration with or without strenuous exercise promotes overexpression of nephrin and podocin genes and induces structural and functional Tofighi A.et al,Toxicol Lett,2017
- Restoration of Spermatogenesis Using a New Combined Herbal Formula of Epimedium koreanum Nakai and Angelica gigas Nakai in an Luteinizing Hyun Jun Park.et al,World J Mens Health,2017
- Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease Zhang Li.et al,Aging Dis,2017
- Dietary Selenium Deficiency or Excess Reduces Sperm Quality and Testicular mRNA Abundance of Nuclear Glutathione Peroxidase 4 in Rats Zhou JC.et al,J Nutr.,2017
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- Ginger extract mitigates ethanol-induced changes of alpha and beta ? myosin heavy chain isoforms gene expression and oxidative stress in the heart of male wistar rats Alireza Shirpoor.et al,DNA Repair,2017
- Effect of intensive endurance training on rat brain and hepatic 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine levels Mohammad Afzalpour.et al,Journal of Applied Pharmaceutical Science ,2016
- Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy Liu J.et al,Anal Bioanal Chem.,2015
- Assessment of benzene induced oxidative impairment in rat isolated pancreatic islets and effect on insulin secretion Haji Bahadar et al,Environmental Toxicology and Pharmacology,2015
- The effect of prenatal exposure to 900-megahertz electromagnetic field on the, 21-old-day rat testicle Hanc謀 H et al,Reprod Toxicol,2013
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靶點詳情
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最新研究進展:8-OHdG是DNA氧化損傷的標志物,最新研究發(fā)現(xiàn),其與肺癌、肝癌、結(jié)直腸癌、卵巢癌等多種癌癥的發(fā)生和發(fā)展有關(guān)。研究人員通過對癌癥患者和對照組進行對比分析,發(fā)現(xiàn)8-OHdG的水平在癌癥患者中明顯升高,因此可以作為腫瘤的生物標志物之一。此外,8-OHdG的水平還可以反映環(huán)境暴露和生活方式對人體DNA的影響。最新研究表明,8-OHdG的水平與吸煙、飲酒、肥胖、缺乏鍛煉等不良生活習慣有關(guān)。因此,8-OHdG的測量可以用作評估生活方式和環(huán)境暴露的生物標志物。另外,一些研究還表明,8-OHdG可能與一些神經(jīng)退行性疾病的發(fā)生和發(fā)展有關(guān),包括帕金森病和阿爾茨海默病。在這些疾病中,氧化應激和DNA氧化損傷可能是致病機制之一,而8-OHdG的測量可以用作評估疾病進展和治療效果的生物標志物。
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