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  4. Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit

Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit

  • 中文名稱：
    小鼠清道夫受體富含半胱氨酸1蛋白M130(CD163)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004882MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
        CD163是一種巨噬細(xì)胞的受體，在炎癥和組織修復(fù)中起著重要作用。它主要存在于巨噬細(xì)胞和單核細(xì)胞表面，并參與炎癥的調(diào)節(jié)、細(xì)胞凋亡和自噬等過程。CD163的表達(dá)量可以反映細(xì)胞的激活狀態(tài)，因此可以用于評估炎癥反應(yīng)和疾病的嚴(yán)重程度。在多種炎癥性疾病中，CD163的表達(dá)量升高，包括風(fēng)濕性關(guān)節(jié)炎、紅斑狼瘡和肝炎等。此外，CD163還可以作為一種腫瘤標(biāo)記物，在肝癌和肺癌等惡性腫瘤的診斷和治療中具有潛在的臨床應(yīng)用價(jià)值。
        華美生物所提供的Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit屬于ELISA檢測試劑盒，采用雙抗夾心法定量檢測鼠血清、血漿、組織勻漿樣本中的CD163，其靈敏度為0.23 ng/ml，檢測范圍為0.93 ng/ml-60ng/ml。
     
  • 別名：
    Cd163 ELISA kit; M130Scavenger receptor cysteine-rich type 1 protein M130 ELISA kit; CD antigen CD163) [Cleaved into: Soluble CD163 ELISA kit; sCD163)] ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.93 ng/ml-60ng/ml
  • 靈敏度：
    0.23 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    CD163是一種單核細(xì)胞的受體，可參與調(diào)節(jié)細(xì)胞的炎癥和免疫反應(yīng)。最新研究表明，CD163在多種疾病的發(fā)生發(fā)展中起重要作用，如肝病、炎癥性腸病、肺炎、骨質(zhì)疏松等。此外，CD163還可能成為腫瘤治療的新靶點(diǎn)，相關(guān)研究正在進(jìn)行中。
  • 功能：
    Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.; After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
  • 基因功能參考文獻(xiàn)：
    1. house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia PMID: 26376364
    2. In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes. PMID: 27354410
    3. During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch signalling necessary for myogenic progenitor cell proliferation. PMID: 26242746
    4. Data indicate an essential substrate motif for ADAM17-mediated CD163 and proTNF-alpha cleavage in macrophages. PMID: 24275664
    5. alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress. PMID: 22807450
    6. Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209. PMID: 21427223
    7. Assignment of the CD163 antigen to mouse chromosome 6 band F2. PMID: 12698011

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  • 亞細(xì)胞定位：
    [Soluble CD163]: Secreted.; Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen and mesenteric lymph nodes.
  • 數(shù)據(jù)庫鏈接：