Mouse Interleukin 1 receptor antagonist, IL-1ra ELISA kit
-
中文名稱:小鼠白介素1受體拮抗劑(IL1Ra)酶聯(lián)免疫試劑盒
-
貨號:CSB-E10395m
-
規(guī)格:96T/48T
-
價(jià)格:¥3800/¥2500
-
其他:
產(chǎn)品詳情
-
產(chǎn)品描述:IL1RN (白細(xì)胞介素1受體拮抗劑,又稱為 IL-1Ra) 是一種由人類基因IL1RN編碼的蛋白質(zhì)。它是 IL-1 家族的拮抗劑,可以結(jié)合 IL-1 受體從而抑制 IL-1 介導(dǎo)的炎癥反應(yīng)。IL1RN 的表達(dá)受多種因素的調(diào)控,包括細(xì)胞類型、炎癥反應(yīng)和遺傳因素等。它與多種疾病的發(fā)生和發(fā)展密切相關(guān),包括關(guān)節(jié)炎、心血管疾病、腫瘤和神經(jīng)炎癥等。華美生物所提供的Mouse Interleukin 1 receptor antagonist, IL-1ra ELISA kit屬于ELISA檢測試劑盒,采用雙抗夾心法定量檢測鼠血清、血漿、組織勻漿樣本中的IL1RN,其靈敏度為15.6 pg/mL,檢測范圍為62.5 pg/mL-4000 pg/mL。
-
別名:Il1rn ELISA Kit; Il-1raInterleukin-1 receptor antagonist protein ELISA Kit; IL-1RN ELISA Kit; IL-1ra ELISA Kit; IRAP ELISA Kit; IL1 inhibitor ELISA Kit
-
縮寫:IL1RN
-
Uniprot No.:
-
種屬:Mus musculus (Mouse)
-
樣本類型:serum, plasma, tissue homogenates
-
檢測范圍:62.5 pg/mL-4000 pg/mL
-
靈敏度:15.6 pg/mL
-
反應(yīng)時(shí)間:1-5h
-
樣本體積:50-100ul
-
檢測波長:450 nm
-
研究領(lǐng)域:Others
-
測定原理:quantitative
-
測定方法:Sandwich
-
精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays):CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL-1ra in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 84 Range % 81-88 1:2 Average % 92 Range % 89-96 1:4 Average % 102 Range % 98-105 1:8 Average % 99 Range % 95-104 -
回收率:
The recovery of mouse IL-1ra spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 87 83-90 EDTA plasma (n=4) 100 95-105 -
標(biāo)準(zhǔn)曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. pg/ml OD1 OD2 Average Corrected 4000 2.547 2.601 2.574 2.413 2000 1.721 1.709 1.715 1.554 1000 1.014 1.102 1.058 0.897 500 0.616 0.628 0.622 0.461 250 0.360 0.371 0.366 0.205 125 0.263 0.260 0.262 0.101 62.5 0.201 0.199 0.200 0.039 0 0.162 0.160 0.161 -
數(shù)據(jù)處理:
-
貨期:3-5 working days
引用文獻(xiàn)
- Comprehensive Process Optimization for Rapidly Vascularized Osseointegration by Dual Ions Effects W Lu,/,/
- Early-life exercise induces immunometabolic epigenetic modification enhancing anti-inflammatory immunity in middle-aged male mice N Zhang,Nature communications,2024
- Reversibility of sarcopenia by Ishige okamurae and its active derivative diphloroethohydroxycarmalol in female aging mice J Hyun,Biomedicine & pharmacotherapy,2022
- Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders A Vladimirovna Pakhomova,Int J Mol Sci.,2020
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
最新研究進(jìn)展:IL1RN是一種由細(xì)胞分泌的蛋白質(zhì),可以調(diào)節(jié)炎癥反應(yīng)。最新研究表明,IL1RN可能在一些疾病的治療中發(fā)揮作用,例如類風(fēng)濕性關(guān)節(jié)炎、糖尿病和肺部疾病等。
-
功能:Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
-
基因功能參考文獻(xiàn):
- Findings identify a critical role for IL1Ra in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 in mucosal Th17 cell induction associated with the development of autoimmune disease in mice. PMID: 28645307
- The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia. PMID: 27482635
- we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells. PMID: 26873573
- results provide evidence of the key role of IL1RA secreted by MSCs to both control the polarization of macrophages toward a M2 phenotype and inhibit B cell differentiation in vivo. PMID: 26661518
- Allo-transplantation of mesenchymal stem cells reduces Con A liver injury by increasing IL10 production through an IL1Ra dependent macrophage switch. PMID: 26276675
- results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra. PMID: 26951334
- While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis and correlates with defective NLRC4-dependent IL-1Ra production. PMID: 26972847
- IL-1Ra deficiencies might promote early plaque development in 16-week-old apoE(-/-) mice. PMID: 26413013
- IL-1Ra is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 signaling cascade. PMID: 26474296
- These findings demonstrated novel roles for F-spondin and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages. PMID: 26042735
- These findings demonstrate a pathogenic mechanism in which adaptive and innate immunity induce an autoimmune disease in a coordinated manner. PMID: 26108163
- Leading to enhanced interleukin-1 receptor antagonist (IL-1RA) production. PMID: 25909959
- IL-1Ra may have a protective effect upon EBOV infection. PMID: 26209680
- IL-1ra regulates baseline GABAergic transmission in the central amygdala and is critical for the ethanol effects at these synapses. PMID: 25479427
- normalization of IL-1Ra in obesity improved insulin sensitivity due to decreased inflammation in the liver and improved hepatic insulin sensitivity and these effects were independent of changes in body weight. PMID: 25244011
- Loss of IL-1ra gene is associated with spontaneous arthritis. PMID: 21414240
- We demonstrate that Aspergillus fumigatus galactosaminogalactan inhibits cytokines production by inducing Interleukin-1 receptor antagonist PMID: 24603878
- IL-1Ra deficiency promoted the expression of inflammatory cytokines beyond IL-1 and altered the expression of genes involved in bone resorption in A. actinomycetemcomitans-infected osteoblasts. PMID: 24566623
- IL-1rn(-/-) mice develop spinal abnormalities that resemble characteristic features associated with human intervertebral disc degeneration. PMID: 23396662
- Modulation of the IL-1ra pathway by classical IL-6 signalling demonstrates anti-inflammatory and protective activities of IL-6 in vivo. PMID: 22980031
- In the mouse ischemic heart and in a mouse cardiomyocyte cell line exposed to long-lasting hypoxia, IL-1ra bound and inhibited mitochondria-activated caspases. PMID: 23308180
- Balb/c mice deficient in IL-1ra (mouse gene of IL-1RN) develop spontaneous autoimmune arthritis while DBA/1 mice deficient in IL-1ra do not PMID: 22942082
- The results showed that CCR5 deficiency caused apoptotic cell death of melanoma through inhibition of NF-kappaB and upregulation of IL-1Ra. PMID: 22567084
- The results showed that the local production of IL-1Ra by hepatocytes contributes to the resolution of hepatitis. The injured liver produced large amounts of IL-1Ra. The IL-1Ra isoforms were produced with different kinetics. PMID: 22539301
- IL-1Ra plays an important role in suppressing local responses in eyes injected with LPS. PMID: 22267332
- This gene is known to be important for immune responses and may potentially regulate alcohol consumption. PMID: 21309947
- An imbalance in IL-1/IL-1Ra signaling at the IL-1R1 level modulates the severity of cardiac remodeling after acute myocardial infarction in the mouse. PMID: 22140485
- Energy-sensing factors coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist. PMID: 22117073
- infection of IL-1RA(-/-) mice with Leishmania major led to significantly worsened disease outcome with larger lesions, dramatically higher parasite burdens, and decreased IFN-gamma production by antigen-specific T cells PMID: 21525884
- study demonstrates that intestinal epithelia, despite not expressing IL-1beta, secrete sIL-1Ra in a TLR5-dependent manner suggesting that loss of TLR5 may promote inflammation by increasing IL-1beta activity PMID: 20844479
- these results show a protective effect of the IL-1ra in vivo in TLR9-associated liver injury. PMID: 20727895
- Findins define distinct roles for two major cellular sources of IL-1Ra in response to different types of systemic inflammatory stimuli in vivo. PMID: 20639493
- The development of psoriasis-like lesions in IL-1R antagonist (Il1rn)-deficient mice is dependent on locally produced tumor necrosis factor (TNF), but not on IL-6 or IL-17. PMID: 20610641
- TLR4-mediated interleukin-1 receptor antagonist production plays a negative regulatory role in low molecular weight hyaluronan (200 kDa)-induced mouse lung inflammation, promoting an anti-inflammatory response. PMID: 20357263
- IL-1Ra deficiency in inflammatory cells induced aortic valve inflammation and TNF-alpha participates in the development of aortic stenosis in IL-1Ra(-/-) mice. PMID: 20110570
- MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages PMID: 19922413
- Effect of MPC-11 myeloma and MPC-11 + IL-1 receptor antagonist treatment on mouse bone properties. PMID: 11792572
- Balance between endogenous IL-1 and IL-1Ra during the primary immune response can help determine the antigen-specific effector function of T cells. PMID: 11810022
- Regulation of transcription of the intracellular interleukin-1 receptor antagonist gene by AP-1 PMID: 11933077
- Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size PMID: 11983917
- highly expressed not only in liver and spleen, but also in white adipose tissue (WAT), where it is upregulated in obesity PMID: 12716739
- Absence of IL-1Ra promoted neointimal formation in mice after arterial injury PMID: 12874179
- CB1 and CB2 receptors modulate release of endogenous IL-1ra from primary cultured glial cells; endogenous IL-1ra is essential for the neuro-protective effects of CBs against excessive activation of glutamate receptors in cultured neurons PMID: 12878687
- Sleep deprivation markedly increased interleukin 1 receptor antagonist, a natural (anti-inflammatory) modulator of interleukin-1. PMID: 14583241
- IL-1Ra plays a role in the suppression of lesion development during early atherogenesis & in the modulation of plaque composition. PMID: 15059807
- Data suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40. PMID: 15578092
- hepatocyte-derived IL-1ra may control optimal activation and migration of inflammatory dendritic cells within the liver and thereby determine the local immune responses in granulomatous liver disease PMID: 15749858
- IL-1Ra is an important regulator of adipogenesis, food intake, and energy expenditure, as seen in knockout mice. PMID: 16306368
- IL-1Ra reduces insulin sensitivity in rats through a muscle-specific decrease in glucose uptake. PMID: 16385385
- absence of IL-1ra may suppress TGF-beta-mediated signaling pathway, which is crucial for collagen deposition and vascular endothelial growth factor-mediated neovascularization in wound heali PMID: 16622029
顯示更多
收起更多
-
亞細(xì)胞定位:[Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm.
-
蛋白家族:IL-1 family
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
Human Transforming Growth factor β1,TGF-β1 ELISA kit
Detect Range: 23.5 pg/ml-1500 pg/ml
Sensitivity: 5.8 pg/ml
-
-
-
Mouse Tumor necrosis factor α,TNF-α ELISA Kit
Detect Range: 7.8 pg/ml-500 pg/ml
Sensitivity: 1.95 pg/ml
-
-
-
-