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  4. Mouse Cluster of differentiation 30,CD30 ELISA Kit

Mouse Cluster of differentiation 30,CD30 ELISA Kit

  • 中文名稱(chēng)：
    小鼠CD30分子(CD30)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E04525m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 別名：
    Tnfrsf8 ELISA Kit; Tumor necrosis factor receptor superfamily member 8 ELISA Kit; CD30L receptor ELISA Kit; Lymphocyte activation antigen CD30 ELISA Kit; CD antigen CD30 ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 檢測(cè)范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
  • 基因功能參考文獻(xiàn)：
    1. This study demonstrated the amelioration of MOG35-55 peptide-induced active EAE in CD30 KO mice. CD30 was expressed limitedly on CD4 T cells at the induction phase of experimental autoimmune encephalomyelitis. PMID: 26857493
    2. Data indicate that CD30L/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). PMID: 25533628
    3. role in the maintenance and activation of IL-17A-producing gammadelta T cells PMID: 23549449
    4. These results suggest that CD30 signaling plays an important role in the activation of IL-17A-producing Vgamma1(-) Vgamma4(-) gammadelta T cells bearing Vgamma6 at an early stage of BCG infection. PMID: 23918785
    5. Interference of the CD30-CD30L pathway reduces atherosclerosis development. PMID: 23087358
    6. CD30L/CD30 pathway acts as an accelerator of enteritis in a murine disease model PMID: 22451116
    7. role of CD30L/CD30 interactions in allergic rhinitis; results suggest that CD30L plays an important role in allergic rhinitis PMID: 21739429
    8. Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice. PMID: 21788408
    9. Studies demonstrate that CD30L/CD30 signaling executed by the T-T cell interaction plays a critical role in Th17 cell differentiation. PMID: 20639486
    10. CD30 can signal in a completely TCR-independent fashion to induce IL-13 production by effector T cells. PMID: 12193714
    11. Immunity to CD30 could play a role in Marek disease lymphoma regression. PMID: 15356338
    12. Deficiencies in OX40 and CD30 signals were additive, secondary Ab responses were ablated.OX40/CD30 double-knockout OTII transgenic T cells fail to survive compared with normal T cells when cocultured with CD4(+)CD3(-) cells in vitro. PMID: 15778343
    13. CD30 plays an important role in the generation of long-lived memory CD8+ T cells, at least partly by triggering homing receptors for T(central memory) cells. PMID: 16177108
    14. early CD30 signaling is critical for regulatory T cells-mediated acute graft-versus-host disease protection after major MHC-mismatch bone marrow transplantation PMID: 17068147
    15. These results indicate that CD30 is a regulator of T(h)2 responses in the effector-memory phase and a regulator of IL-13 production in memory cells in the lung. PMID: 18089617
    16. CD30L/CD30 signaling is involved in development of both OXA- and TNBS-induced colitis. Modulation of CD30L/CD30 signaling by mAb could be a novel biologic therapy for inflammatory bowel diseases. PMID: 18242212
    17. CD30 and OX40 signals are both required for the survival but not commitment of CD4 T helper type 1 (Th1) cells. PMID: 18292503
    18. Signaling executed by CD30positive T cell interaction with CD30Lpositive T cells plays a critical role in amplification of T helper type (Th)1 responses that able to produce interferon-gamma against Mycobacterium bovis bacillus Calmette-Guerin infection. PMID: 18941223
    19. ko mice exhibite delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes after infection with erogenic Mycobacterium avium PMID: 19250702
    20. CD30 signals from lymphoid tissue inducer cells were a primitive mechanism to recruit and prime CD4 T cells PMID: 19342654
    21. Data demonstrate that the crucial role of CD30 signaling in the development of acute asthma may be taken over by other costimulatory molecules like OX40 after long-term exposure to the antigen. PMID: 19544310
    22. Following infection with murine cytomegalovirus, CD30 is necessary for preserving the lymphoid microenvironment by enhancing the protective function of NK cells. PMID: 19731363
    23. signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria. PMID: 19786532

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in thymus and in activated splenocytes.
  • 數(shù)據(jù)庫(kù)鏈接：