XPO1
XPO1，即染色體區(qū)域維持1蛋白（Chromosome Region Maintenance 1 Protein），也被稱為出口蛋白1（Exportin 1），是一種在細胞核輸出過程中發(fā)揮關(guān)鍵作用的蛋白質(zhì)。它通過識別并結(jié)合含有核輸出信號的貨物，如某些RNA和蛋白質(zhì)，將它們從細胞核運輸?shù)郊毎|(zhì)中。XPO1的來源是細胞自身的基因編碼，它在細胞分裂、基因表達調(diào)控、細胞信號傳遞等方面發(fā)揮著重要作用。其作用機制涉及到與Ran GTPase蛋白的相互作用，以及與貨物蛋白的結(jié)合和釋放，從而實現(xiàn)物質(zhì)的定向運輸。XPO1在生物學(xué)上的意義非常廣泛，它涉及到細胞內(nèi)多種信號通路的調(diào)控，包括但不限于p53信號通路、NF-κB信號通路等，這些信號通路與細胞的生長、分化、凋亡以及對外界刺激的響應(yīng)密切相關(guān)。XPO1的功能異常與多種疾病相關(guān)，特別是在癌癥中，XPO1的過表達與腫瘤的侵襲性、轉(zhuǎn)移和化療抵抗性有關(guān)。因此，XPO1成為了抗癌藥物開發(fā)的重要靶點，通過抑制XPO1的活性，可以阻止腫瘤相關(guān)蛋白的核輸出，進而影響腫瘤細胞的生長和存活。
熱銷產(chǎn)品
XPO1 Recombinant Monoclonal Antibody (CSB-RA930964A0HU)
驗證數(shù)據(jù)
IHC image of CSB-RA930964A0HU diluted at 1:100 and staining in paraffin-embedded human ovarian tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA930964A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
XPO1 Antibodies
XPO1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA026221GA01HU | XPO1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000147 | Acetyl-XPO1 (K568) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA360041 | XPO1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA026221LA01HU | XPO1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA026221LB01HU | XPO1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA026221LC01HU | XPO1 Antibody, FITC conjugated | Human | |
| CSB-PA026221LD01HU | XPO1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA930964A0HU | XPO1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
XPO1 Proteins
XPO1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP026221HU CSB-EP026221HU CSB-BP026221HU CSB-MP026221HU CSB-EP026221HU-B |
Recombinant Human Exportin-1 (XPO1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP026221SXV CSB-EP026221SXV CSB-BP026221SXV CSB-MP026221SXV CSB-EP026221SXV-B |
Recombinant Schizosaccharomyces pombe Exportin-1 (xpo1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP706698DKK CSB-EP706698DKK CSB-BP706698DKK CSB-MP706698DKK CSB-EP706698DKK-B |
Recombinant Dictyostelium discoideum Exportin-1 (xpo1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP750809MO CSB-EP750809MO CSB-BP750809MO CSB-MP750809MO CSB-EP750809MO-B |
Recombinant Mouse Exportin-1 (Xpo1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP802224RA CSB-EP802224RA CSB-BP802224RA CSB-MP802224RA CSB-EP802224RA-B |
Recombinant Rat Exportin-1 (Xpo1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
