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RIPK1

RIPK，即受體相互作用絲氨酸/蘇氨酸蛋白激酶1，別名RIP1。RIPK1是一種胞質(zhì)蛋白激酶，能夠調(diào)節(jié)多種炎癥和細(xì)胞死亡途徑。它在腫瘤壞死因子受體1 (TNFR1) 信號通路中的作用已被廣泛研究，其激酶活性對調(diào)控過程至關(guān)重要。RIPK1可以參與形成多種信號復(fù)合體，如復(fù)合體I（TNF-RSC），通過泛素化修飾促進(jìn)NF-κB激活和抑制其激酶活性，從而抑制胚胎發(fā)生和炎癥過程中RIPK1依賴的細(xì)胞死亡。RIPK1在生物學(xué)上的意義非常重大，它不僅參與細(xì)胞凋亡、壞死性凋亡（necroptosis）以及炎癥信號通路的調(diào)控，還涉及胚胎發(fā)育、造血系統(tǒng)發(fā)育以及免疫穩(wěn)態(tài)的維持等多種重要生物學(xué)過程。RIPK1的功能異常與多種疾病有關(guān)，包括自身免疫缺陷、自身炎癥性疾病、漸凍癥、風(fēng)濕性關(guān)節(jié)炎以及結(jié)腸炎等。靶向RIPK1的小分子藥物正在臨床試驗(yàn)階段，用于治療這些疾病。此外，RIPK1的磷酸化、泛素化等翻譯后修飾對其活性的調(diào)節(jié)在生理和病理?xiàng)l件下均發(fā)揮關(guān)鍵作用。

熱銷產(chǎn)品

Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), partial (CSB-EP618785HU2)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

RIPK1 Antibody (CSB-PA618785LA01HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, Hela whole cell lysate, K562 whole cell lysate, Jurkat whole cell lysate, 293 whole cell lysate, Rat liver tissue, Mouse heart tissue, Mouse kidney tissue
All lanes: RIPK1 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76, 71 kDa
Observed band size: 76 kDa

Immunofluorescence staining of HepG2 cells with CSB-PA618785LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RIPK1 Antibody

RIPK1 Protein

RIPK1 Antibodies

RIPK1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA019735GA01HU	RIPK1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA618785LA01HU	RIPK1 Antibody	Human, Rat, Mouse	ELISA, WB, IF
CSB-PA618785LB01HU	RIPK1 Antibody, HRP conjugated	Human	ELISA
CSB-PA618785LC01HU	RIPK1 Antibody, FITC conjugated	Human
CSB-PA618785LD01HU	RIPK1 Antibody, Biotin conjugated	Human	ELISA

RIPK1 for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA720181LA01MO	Ripk1 Antibody	Mouse, Human	ELISA, WB, IP
CSB-PA720181LB01MO	Ripk1 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA720181LC01MO	Ripk1 Antibody, FITC conjugated	Mouse
CSB-PA720181LD01MO	Ripk1 Antibody, Biotin conjugated	Mouse	ELISA

RIPK1 Proteins

RIPK1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP618785HU CSB-EP618785HU CSB-BP618785HU CSB-MP618785HU CSB-EP618785HU-B	Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP618785HU2	Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), partial	E.coli
CSB-BP618785HUc7	Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	Baculovirus
CSB-BP618785HUc7	Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	Baculovirus

RIPK1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP720181MO	Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1)	Yeast
CSB-EP720181MO	Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1)	E.coli
CSB-MP720181MO CSB-EP720181MO-B	Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1)	Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP720181MOa2	Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1)	E.coli