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PTK2

PTK2,即蛋白酪氨酸激酶2,別名FAK、FRNK、Fadk、FADK1、p125FAK。它是一種非受體型蛋白酪氨酸激酶,由人體細(xì)胞自身的基因編碼,廣泛表達(dá)于多種組織中,包括消化系統(tǒng)、中樞神經(jīng)系統(tǒng)、眼睛、泌尿生殖系統(tǒng)等。PTK2通過其酪氨酸激酶活性,參與細(xì)胞的黏附、遷移和增殖等過程,對(duì)細(xì)胞群增殖、泛素依賴性蛋白質(zhì)分解過程以及蛋白質(zhì)磷酸化具有正向調(diào)控作用。PTK2在血管形態(tài)發(fā)生、神經(jīng)元生成以及肽基酪氨酸自磷酸化等過程中發(fā)揮作用,其活性受多種因素的調(diào)控,包括細(xì)胞外基質(zhì)、生長因子和細(xì)胞內(nèi)信號(hào)分子等。PTK2的功能異常與多種疾病有關(guān),包括平滑肌瘤、肺小細(xì)胞癌和肺動(dòng)脈高壓等,因此,PTK2是藥物開發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn) 。

熱銷產(chǎn)品

PTK2 Recombinant Monoclonal Antibody (CSB-RA198162A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA198162A0HU

IHC image of CSB-RA198162A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

PTK2 Antibodies

PTK2 for Chicken

PTK2 for Homo sapiens (Human)

PTK2 Proteins

PTK2 Proteins for Gallus gallus (Chicken)

PTK2 Proteins for Mus musculus (Mouse)

PTK2 Proteins for Rattus norvegicus (Rat)

PTK2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

PTK2 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

PTK2 Proteins for Xenopus laevis (African clawed frog)

PTK2 ELISA Kit

PTK2 ELISA Kit for Gallus gallus (Chicken)