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PRLR

PRLR,即催乳素受體,是一種主要在垂體前葉以外的多種組織中表達(dá)的跨膜蛋白。催乳素受體通過與催乳素(PRL)結(jié)合,啟動細(xì)胞內(nèi)的信號傳導(dǎo)過程,主要通過JAK2-STAT信號通路發(fā)揮作用,導(dǎo)致細(xì)胞核內(nèi)特定基因的轉(zhuǎn)錄激活,從而影響細(xì)胞增殖、分化和功能。PRLR的信號轉(zhuǎn)導(dǎo)還涉及MAPK和PI3K/AKT等其他信號通路,這些通路在調(diào)節(jié)免疫反應(yīng)、細(xì)胞生長和代謝等方面發(fā)揮作用。催乳素受體的生物學(xué)意義廣泛,它不僅在乳腺發(fā)育和泌乳中發(fā)揮關(guān)鍵作用,還參與調(diào)節(jié)生殖系統(tǒng)、免疫系統(tǒng)和神經(jīng)系統(tǒng)的功能。PRLR的功能異常與多種疾病有關(guān),包括某些類型的癌癥和生殖功能障礙。

熱銷產(chǎn)品

Recombinant Human Prolactin receptor (PRLR), partial (Active) (CSB-MP018727HU1d7)

驗(yàn)證數(shù)據(jù)

CSB-MP018727HU1d7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP018727HU1d7

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PRLR at 2 μg/ml can bind Anti-PRLR recombinant antibody (CSB-RA018727A0HU), the EC50 is 126.8-171.9 ng/mL.

PRLR Recombinant Monoclonal Antibody (CSB-RA018727A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA018727A0HU

The Binding Activity of Human PRLR with Anti-PRLR recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human PRLR (CSB-MP018727HU1d7) at 2 μg/mL can bind Anti-PRLR recombinant antibody, the EC50 is 126.8-171.9 ng/mL.

CSB-RA018727A0HU

The Binding Activity of Mouse Prlr with Anti-PRLR recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Prlr at 5 μg/mL (CSB-MP018727MO) can bind Anti-PRLR recombinant antibody, the EC50 is 4.021-8.706 ng/mL.

PRLR Antibodies

PRLR for Homo sapiens (Human)

PRLR Proteins

PRLR Proteins for Oryctolagus cuniculus (Rabbit)

PRLR Proteins for Homo sapiens (Human)

PRLR Proteins for Ovis aries (Sheep)

PRLR Proteins for Rattus norvegicus (Rat)

PRLR Proteins for Sus scrofa (Pig)

PRLR Proteins for Meleagris gallopavo (Common turkey)

PRLR Proteins for Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)

PRLR Proteins for Columba livia (Domestic pigeon)

PRLR Proteins for Mus musculus (Mouse)

PRLR Proteins for Bos taurus (Bovine)

PRLR Proteins for Cervus elaphus (Red deer)