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MIF

巨噬細(xì)胞遷移抑制因子(Macrophage migration inhibitory factor,MIF)是一種具有廣泛功能的細(xì)胞因子,該因子在炎癥及免疫方面有不可替代的作用。人體中,細(xì)菌抗原刺激白細(xì)胞釋放MIF到血流中。循環(huán)的MIF結(jié)合其它免疫細(xì)胞上的CD74進(jìn)而引發(fā)急性免疫反應(yīng),因此MIF是一種炎性細(xì)胞因子。此外,糖皮質(zhì)激素(Glucocorticoid,GC)也可刺激白細(xì)胞釋放MIF。MIF通過抑制糖皮質(zhì)激素的消炎效果來調(diào)節(jié)巨噬細(xì)胞在宿主防御中的功能。而MIF是截至目前被認(rèn)為唯一能負(fù)向調(diào)節(jié)GC抗炎作用的細(xì)胞因子。除了在炎癥的調(diào)控中起作用,MIF編碼的主要組織相容性復(fù)合體(MHC)Ⅰ及Ⅱ類分子,在抗腫瘤細(xì)胞毒作用中起著限制性識別和介導(dǎo)殺傷的重要作用,亦參與了腫瘤發(fā)生發(fā)展過程。

Recombinant Human MIF 活性蛋白實驗驗證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized MIF at 2 μg/ml can bind Anti- MIF Rabbit Monoclonal Antibody(CSB-RA146975A0HU), the EC50 is 49.61-69.45 ng/ml.


MIF Antibodies

MIF for Homo sapiens (Human)

MIF for Mus musculus (Mouse)

MIF Proteins

MIF Proteins for Sus scrofa (Pig)

MIF Proteins for Bos taurus (Bovine)

MIF Proteins for Homo sapiens (Human)

MIF Proteins for Mus musculus (Mouse)

MIF Proteins for Rattus norvegicus (Rat)

MIF Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

MIF Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

MIF Proteins for Wuchereria bancrofti

MIF Proteins for Ovis aries (Sheep)

MIF Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

MIF Proteins for Macaca mulatta (Rhesus macaque)

MIF Proteins for Xenopus laevis (African clawed frog)

MIF ELISA Kit

MIF ELISA Kit for Homo sapiens (Human)

MIF ELISA Kit for Mus musculus (Mouse)

MIF ELISA Kit for Rattus norvegicus (Rat)