HCN1
HCN1,即超極化激活型環(huán)核苷酸門控通道1,別名If、Ih、HCN1等。它是一種由HCN1基因編碼的膜蛋白,屬于超極化激活型環(huán)核苷酸門控通道家族成員,在心臟和大腦等組織中表達。HCN1的作用機制是在細胞膜超極化時激活,允許鈉和鉀離子通過,對心臟節(jié)律和神經(jīng)元興奮性具有調(diào)節(jié)作用。HCN1參與了心臟的自主節(jié)律控制和心臟起搏,同時在神經(jīng)系統(tǒng)中調(diào)節(jié)神經(jīng)元的發(fā)放頻率和信號傳遞。HCN1的功能異常與心臟疾病中的竇性心動過緩、長QT綜合征,以及神經(jīng)系統(tǒng)疾病中的癲癇有關(guān),是心臟學(xué)和神經(jīng)生物學(xué)研究中的一個重要分子靶點。
熱銷產(chǎn)品
HCN1 Antibody (CSB-PA010216LA01HU)
驗證數(shù)據(jù)
IHC image of CSB-PA010216LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA010216LA01HU diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA010216LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
HCN1 Antibodies
HCN1 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA202569 | HCN1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA409812 | HCN1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA010216LA01HU | HCN1 Antibody | Human | ELISA, IHC, IF |
CSB-PA010216LB01HU | HCN1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA010216LC01HU | HCN1 Antibody, FITC conjugated | Human | |
CSB-PA010216LD01HU | HCN1 Antibody, Biotin conjugated | Human | ELISA |
HCN1 Proteins
HCN1 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP010216HU CSB-EP010216HU CSB-BP010216HU CSB-MP010216HU CSB-EP010216HU-B |
Recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |