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BRAF

BRAF,即B型快速反應(yīng)蛋白激酶,它是一種絲氨酸/蘇氨酸激酶,屬于RAF家族成員。BRAF由BRAF基因編碼,廣泛存在于多種組織中,尤其是在神經(jīng)細胞和皮膚細胞中。其作用機制涉及與RAS蛋白的激活形式結(jié)合后,發(fā)生磷酸化和二聚化,進而激活下游的MEK/ERK信號通路,該通路在細胞增殖、分化、遷移和凋亡等過程中發(fā)揮關(guān)鍵作用。BRAF的生物學(xué)意義在于其在調(diào)控細胞周期、細胞應(yīng)激反應(yīng)以及細胞內(nèi)信號傳遞中的核心作用。BRAF基因的突變,特別是在其激酶結(jié)構(gòu)域中,與多種癌癥的發(fā)生發(fā)展有關(guān),如黑色素瘤、結(jié)直腸癌等,因此BRAF也是癌癥治療中的一個重要靶點。

熱銷產(chǎn)品

BRAF Recombinant Monoclonal Antibody (CSB-RA171021A0HU)

驗證數(shù)據(jù)

CSB-RA171021A0HU

IHC image of CSB-RA171021A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA171021A0HU

IHC image of CSB-RA171021A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human Serine/threonine-protein kinase B-raf(BRAF) ELISA kit (CSB-EL002791HU)

驗證數(shù)據(jù)

CSB-EL002791HU 標準曲線

貨號:CSB-EL002791HU

規(guī)格:96T/48T

靈敏度:7.8 pg/mL

檢測范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

BRAF Antibodies

BRAF for Homo sapiens (Human)

BRAF Proteins

BRAF Proteins for Gallus gallus (Chicken)

BRAF Proteins for Homo sapiens (Human)

BRAF Proteins for Mus musculus (Mouse)

BRAF Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

BRAF Proteins for Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

BRAF ELISA Kit

BRAF ELISA Kit for Homo sapiens (Human)