ADGRE4P

ADGRE4P is a gene encoding a protein named putative adhesion G protein-coupled receptor E4P or G-protein coupled receptor 127 (GPR127), which is a member of the EGF-TM7 receptor gene family and thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene.