ACKR2

ACKR2是一個(gè)編碼β趨化因子受體的基因，預(yù)測(cè)該蛋白質(zhì)是與G蛋白偶聯(lián)受體類似的七次跨膜蛋白。該蛋白質(zhì)在多種組織和造血細(xì)胞中表達(dá)。該受體在淋巴內(nèi)皮細(xì)胞中的表達(dá)，以及在血管腫瘤中的過(guò)度表達(dá)，表明了它在趨化因子驅(qū)動(dòng)的白細(xì)胞再循環(huán)和可能影響血管腫瘤發(fā)展和生長(zhǎng)的趨化因子作用中的功能。新興證據(jù)表明，該蛋白質(zhì)在銀屑病患者的炎癥變化中起著分子調(diào)節(jié)器的作用。
ACKR2 is a gene encoding a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. Emerging evidence has demonstrated that this protein plays a role in inflammatory changes in patients with psoriasis as a molecular regulator.