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  4. Recombinant Mouse Interferon alpha/beta receptor 1 (Ifnar1)

Recombinant Mouse Interferon alpha/beta receptor 1 (Ifnar1)

  • 中文名稱：
    小鼠Ifnar1重組蛋白
  • 貨號：
    CSB-CF011046MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Ifnar1
  • Uniprot No.：
  • 別名：
    Ifnar1; Ifar; Ifnar; Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Type I interferon receptor 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    27-590
  • 氨基酸序列
    ENLKPPENIDVYIIDDNYTLKWSSHGESMGSVTFSAEYRTKDEAKWLKVPECQHTTTTKCEFSLLDTNVYIKTQFRVRAEEGNSTSSWNEVDPFIPFYTAHMSPPEVRLEAEDKAILVHISPPGQDGNMWALEKPSFSYTIRIWQKSSSDKKTINSTYYVEKIPELLPETTYCLEVKAIHPSLKKHSNYSTVQCISTTVANKMPVPGNLQVDAQGKSYVLKWDYIASADVLFRAQWLPGYSKSSSGSRSDKWKPIPTCANVQTTHCVFSQDTVYTGTFFLHVQASEGNHTSFWSEEKFIDSQKHILPPPPVITVTAMSDTLLVYVNCQDSTCDGLNYEIIFWENTSNTKISMEKDGPEFTLKNLQPLTVYCVQARVLFRALLNKTSNFSEKLCEKTRPGSFSTIWIITGLGVVFFSVMVLYALRSVWKYLCHVCFPPLKPPRSIDEFFSEPPSKNLVLLTAEEHTERCFIIENTDTVAVEVKHAPEEDLRKYSSQTSQDSGNYSNEEEESVGTESGQAVLSKAPCGGPCSVPSPPGTLEDGTCFLGNEKYLQSPALRTEPALLC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. Contributes to modulate the innate immune response to bacterial lipopolysaccharide.
  • 基因功能參考文獻：
    1. Only type-I interferon restricts viral replication of attenuated Measles virus (MV) Schwarz strain in mice, independently of the presence of hCD46 receptor. PMID: 30199752
    2. A key role of the IL7 and Interferon type I receptor axis in the regulation of intratumoral t-cell functions and in the development of primary breast tumor growth and metastasis. PMID: 29070614
    3. Data, including data from studies in knockout and double-knockout mice, suggest complex and sex-specific roles of Ifnar1 and Ifnar2 in type 1 diabetes (T1D); female NOD mice develop T1D in absence of both Ifnar1 and Ifnar2, whereas male mice do not. PMID: 30084830
    4. we uncovered that IFNAR1 expression in stromal benign cells functions to protect against progression of leukemia. PMID: 28503979
    5. Concurrent ablation of Ifnar1 led to a modest attenuation of the CK1alpha-null phenotype indicating that, although other CK1alpha targets are likely to be important, IFNAR1 downregulation can contribute to the maintenance of the HSCs function. PMID: 28678581
    6. Central nervous system signaling through IFNAR1 is a factor that is critical to neural injury after stroke. PMID: 28647375
    7. a deleterious role for the type-1 IFNs as key modulators of the early neuroinflammatory response and therefore the neuronal cell death in Parkinson's disease PMID: 27404846
    8. results clearly demonstrate that: (i) MHV-68, MHV-72 and MHV-4556 differentially interact with intracellular signaling and dysregulate IFN signal transduction; (ii) MHV-68, MHV-72 and MHV-4556 degrade type I IFN receptor in very early stages of infection (2-4hpi), but not type III IFN receptor PMID: 27152708
    9. Results show that removal of type-1 IFN signalling in the APPSWE/PS1DeltaE9 mouse model of AD confers a predominantly anti-inflammatory glial response and protects from cognitive decline. However this phenotype does not correlate with alterations in amyloid deposition and only a modest reduction in Abeta monomer levels. PMID: 27400725
    10. transfusion-induced differentiation of IFNAR1(-/-) B cells into germinal center B cells and plasma cells was significantly reduced, compared to WT B cells. This study demonstrates that B cells require signaling from IFN-alpha/beta to produce alloantibodies to the human KEL glycoprotein in mice. PMID: 28836263
    11. study provides evidence of STING activation in T cells, in which STING agonists not only provoke type I IFN production and IFN-stimulated gene expression, mirroring the response of innate cells, but are also capable of activating cell stress and death pathways. PMID: 28615418
    12. These data suggest that plasmacytoid dendritic cells producing IFN-alpha and IL-33 play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis. PMID: 28373582
    13. type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine expression including CCL2. PMID: 26992431
    14. these studies demonstrate an important role for type I IFN in skin fibrosis, and they provide a rationale for IFNAR1 inhibition in scleroderma PMID: 27226090
    15. These results identify a key interface created by IFNAR1 residues Tyr(240) and Tyr(274) interacting with IFN-beta residues Phe(63), Leu(64), Glu(77), Thr(78), Val(81), and Arg(82) that underlie IFN-beta-IFNAR1-mediated signaling and biological processes. PMID: 28289093
    16. IFNAR1-deficiency accelerated humoral immune responses and parasite control by boosting ICOS-signalling in two non-lethal murine models of malaria PMID: 27812214
    17. reduced type I interferon production in obesity is caused by SOCS3 overexpression as well as tolerance induced by leptin PMID: 27704310
    18. These identify A129 mice as being highly susceptible to ZIKV and thus A129 mice represent a suitable, and urgently required, small animal model for the testing of vaccines and antivirals. PMID: 27149521
    19. Downregulation of IFNAR1 promotes melanoma development and progression. IFNAR1 mutation, which is partially resistant to downregulation, delays melanoma development. PMID: 27052162
    20. Data demonstrate that Type-1 interferons signaling is a critical pathway in the progression of neuroinflammation and presents a viable therapeutic target for the treatment of traumatic brain injury. PMID: 27022620
    21. The study provides evidence for the importance of brain endothelial and epithelial cells in the communication between the Central Nervous System and the immune system, and demonstrates tissue specific IFNAR1 engagement during sickness behavior. PMID: 27096319
    22. Data show that both NF-kappaB (NF-kappaB) and tonic interferon signals are involved in the final maturation of thymocytes into naive T cells. PMID: 27043411
    23. role in megakaryo- and thrombopoiesis PMID: 26134179
    24. ablation of Ifnar1 partially protected mice from caerulein-induced pancreatitis, as demonstrated by reduced tissue damage and macrophage recruitment. PMID: 26618925
    25. IFNAR signaling directly modulates T lymphocyte activity, resulting in milder experimental autoimmune encephalomyelitis development PMID: 26232452
    26. IFN-I receptor 1 deficient mice (IFNAR1(-/-)) displayed significantly attenuated poly I:C-induced hypothermia, hypoactivity and weight loss compared to WT C57BL/6 mice. PMID: 25900439
    27. Data suggest MyD88 (myeloid differentiation primary response protein) is redundant for Ifnar1/IFN-I (interferon type I) responses and overall defense/innate immunity against systemic mouse Cytomegalovirus infection; this is consistent with human data. PMID: 25954804
    28. IFNAR1 signaling in microglia is essential for ischemic preconditioning in white matter. PMID: 26609155
    29. Lack of IFNB or IFNAR was associated with reduced neurogenesis in the hippocampus; dentate gyrus PMID: 26451483
    30. Taken together, our studies provide novel insights on how type I IFN receptor signaling regulates NK cell development and functions PMID: 25333658
    31. IFN-alpha/beta is able to drive the formation of a Stat2 and IRF-9 complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics. PMID: 26019270
    32. our findings describe a novel role for IFN during metastasis development and suggest that new treatment strategies should be considered for prevention of metastasis formation in patients. PMID: 25604426
    33. TNFR1- and IFNAR1-deficient mice showed partial protection toward Aldara-induced inflammation compared with control groups. Double knockout mice lacking both receptors showed superior protection to Aldara in comparison with the single knockout mice. PMID: 25911755
    34. Impaired clearance of the high pathogenicity H1N1 influenza A virus prolonged IFN expression, leading to CCR2+ inflammatory monocytes amplifying their own recruitment via an interferon-alpha/beta receptor 1 (IFNAR1)-triggered chemokine loop. PMID: 25407417
    35. IFN-alpha/beta receptor signaling promotes regulatory T cell development and function under stress conditions. PMID: 25795758
    36. enhances cytotoxic activities of NK and CD8+ T cells but suppresses IFN-gamma production by these cells via the induction of IL-10 PMID: 24435166
    37. IRF7 suppresses antiparasitic immunity in the spleen, while IFNAR1-mediated, but IRF7-independent, signaling contributes to pathology in the brain during experimental blood-stage malaria. PMID: 25319247
    38. The C5a anaphylatoxin receptor (C5aR1) protects against Listeria monocytogenes infection by inhibiting interferon-alpha and interferon-beta expression. PMID: 25297874
    39. IFNAR1 joins several other genetic risk factors of Inflammatory Bowel Diseases whose products profoundly affect the intestinal microbiota and or Paneth cell function. PMID: 24555997
    40. Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis. PMID: 24743949
    41. Trigger IFNAR1 ubiquitination for limiting the inflammation-induced tissue damage can be purposely mimicked for therapeutic benefits. PMID: 24480543
    42. Collectively, persistent HBV replication IFNAR(-/-) mouse model that we established is a useful and convenient tool to detect the function of the type I interferon and IFNAR in HBV infection and anti-HBV treatments. PMID: 23771666
    43. TLR7-deficient and IFNAR1-deficient mice were more susceptible to liver fibrosis than wild type mice, indicating that TLR7-type I IFN signaling exerts a protective effect against liver fibrosis. PMID: 24375615
    44. Interferon-alpha but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PMID: 24409099
    45. Type I IFN receptor signaling acts as a central driver of early proinflammatory responses in the lung. PMID: 24648449
    46. Mice lacking the IFN-alpha/beta receptor succumbed to the infection, with vesicular stomatitis virus spreading from the olfactory bulb throughout the brain. PMID: 24429359
    47. IFNAR-/- mice were highly susceptible to severe fever with thrombocytopenia syndrome virus infection, and all mice died within 3 to 4 days after inoculation. PMID: 24257618
    48. This study provided evidence for the production of IFNbeta from glia and using mice deficient in the type I IFN receptor alpha 1 (IFNAR1), demonstrate that its subsequent activation is likely to underlie the TLR3-mediated modulation of hippocampal excitability. PMID: 23554175
    49. Type I interferon signaling and responses limit HIV-1 infection and pathogenesis in brain. PMID: 24335529
    50. Data suggest Ifnar1 plays critical role in regulation of innate immunity; Oasl1 knockout mice mount better virus-specific CD8-positive T-cell response to lymphocytic choriomeningitis virus and this response is blocked if Ifnar1 signaling is blocked. PMID: 23874199

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome.
  • 蛋白家族：
    Type II cytokine receptor family
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:15975

    STRING: 10090.ENSMUSP00000023689

    UniGene: Mm.502