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  4. Recombinant Mouse Integrin alpha-X (Itgax), partial

Recombinant Mouse Integrin alpha-X (Itgax), partial

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  • 中文名稱：
    小鼠Itgax重組蛋白
  • 貨號(hào)：
    CSB-BP874106MO1
  • 規(guī)格：
    ￥3168
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Itgax
  • Uniprot No.：
  • 別名：
    Itgax; Integrin alpha-X; CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD antigen CD11c
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 來源：
    Baculovirus
  • 分子量：
    165.4 kDa
  • 表達(dá)區(qū)域：
    20-1116aa
  • 氨基酸序列
    FNLDAEKLTHFHMDGAEFGHSVLQYDSSWVVVGAPKEIKATNQIGGLYKCGYHTGNCEPISLQVPPEAVNISLGLSLAAATNPSWLLACGPTVHHTCRENIYLTGLCFLLSSSFKQSQNFPTAQQECPKQDQDIVFLIDGSGSISSTDFEKMLDFVKAVMSQLQRPSTRFSLMQFSDYFRVHFTFNNFISTSSPLSLLGSVRQLRGYTYTASAIKHVITELFTTQSGARQDATKVLIVITDGRKQGDNLSYDSVIPMAEAASIIRYAIGVGKAFYNEHSKQELKAIASMPSHEYVFSVENFDALKDIENQLKEKIFAIEGTETPSSSTFELEMSQEGFSAVFTPDGPVLGAVGSFSWSGGAFLYPSNMRPTFINMSQENEDMRDAYLGYSTALAFWKGVHSLILGAPRHQHTGKVVIFTQESRHWRPKSEVRGTQIGSYFGASLCSVDMDRDGSTDLVLIGVPHYYEHTRGGQVSVCPMPGVGSRWHCGTTLHGEQGHPWGRFGAALTVLGDVNGDSLADVAIGAPGEEENRGAVYIFHGASRQDIAPSPSQRISASQIPSRIQYFGQSLSGGQDLTRDGLVDLAVGSKGRVLLLRTRPILRVSPTVHFTPAEISRSVFECQEQVAPEQTLSDATVCLHIHESPKTQLGDLRSTVTFDLALDHGRLSTRAIFKETKTRALTRVKTLGLNKHCESVKLLLPACVEDSVTPITLRLNFSLVGVPISSLQNLQPMLAVDDQTYFTASLPFEKNCGADHICQDDLSVVFGFPDLKTLVVGSDLELNVDVTVSNDGEDSYGTTVTLFYPVGLSFRRVAEGQVFLRKKEDQQWQRRGQHSLHLMCDSTPDRSQGLWSTSCSSRHVIFRGGSQMTFLVTFDVSPKAELGDRLLLRARVGSENNVPGTPKTTFQLELPVKYAVYTMISSHDQFTKYLNFSTSEKEKTSVVEHRFQVNNLGQRDVPVSINFWVPIELKGEAVWTVMVSHPQNPLTQCYRNRLKPTQFDLLTHMQKSPVLDCSIADCLHLRCDIPSLGILDELYFILKGNLSFGWISQTLQKKVLLLSEAEITFNTSVYSQLPGQEAFLRAQTKTVLEMYKVHNPVP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal MBP-tagged and C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
  • 基因功能參考文獻(xiàn)：
    1. CD11c and its partner Itgb2 were required for DC capture of CD47-deficient cells. CD11b was not necessary for this process but could partially compensate in the absence of CD11c. Mice with DCs lacking Talin1, Itgb2, or CD11c were defective in supporting T-cell proliferation and differentiation induced by CD47-deficient cell associated antigen. PMID: 29891680
    2. alphaXbeta2 uses the alphaX alphaI domain to bind iC3b on its C3c moiety at one of two sites. PMID: 28292891
    3. Accumulation of lung CD11c+ DCs is significantly higher in both inflammatory and fibrotic phases of the disease but that percentages got reduced in the absence of TGF-beta. PMID: 28557137
    4. The findings of this study indicate that radio-resistant cells, expressing CD11c-GFP+ and located in the CNS, irrespective of their origin, which might be the yolk sac or the periphery, show a phenotype capable of antigen presentation under neuroinflammatory conditions following induction of EAE. PMID: 28421248
    5. These data demonstrated that the CD11c+ lamina propria mononuclear phagocytes from this postinfectious irritable bowel syndrome mouse model were not only able to transfer enteric inflammation to the normal mice but also caused abnormal intestinal function, characterized by epithelial barrier disruption and visceral hyperalgesia. PMID: 28440501
    6. the CD11c promoter was unexpectedly active and triggered Mgat2 deletion within multiple hematopoietic lineages, showed remarkably poor penetrance within native DC populations, and produced almost undetectable levels of green fluorescent protein signal. These findings show that the CD11c promoter is not DC-specific, and extreme care should be taken in the interpretation of data using any mouse created using the CD11c-CRE PMID: 27146521
    7. Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs). PMID: 28780965
    8. MyD88 signaling in lysozyme M and CD11c-expressing myeloid cells, as well as in pulmonary epithelial cells, is critical to restore inflammatory cytokine and antimicrobial peptide production, leading to efficient neutrophil recruitment and enhanced bacterial clearance. PMID: 26627460
    9. Results implicate a monocytic origin of CD11c(+) cells in inflamed islets and suggest that therapeutic regulatory T cells directly or indirectly regulate their influx by altering the chemotactic milieu in the islets. PMID: 28550204
    10. Murine CD11c+ T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including gammadelta T cells and invariant natural killer T (iNKT) cells. PMID: 27119555
    11. Data concluded that the ablation of CD11c(hi) dendritic cells provided a subsidiary impact on blood-brain barrier (BBB) integrity and the expression of tight junction/adhesion molecules, thereby leading to exacerbated Japanese encephalitis (JE) progression. PMID: 27638116
    12. CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23. PMID: 26242598
    13. data demonstrate that CD11c(hi) DCs provide a critical and unexpected role to preserve the immune-privileged CNS in lethal neuroinflammation via regulating the differentiation, function, and trafficking of CD11b(+)Ly-6C(hi) monocytes. PMID: 26626303
    14. The generation of mouse line with Flip deficiency in cells that express cre under the CD11c promoter is reported. PMID: 25963626
    15. Probucol effectively retarded atherosclerosis at least partly through lipid-lowering and inhibiting immune maturation of CD11c dendritic cells in STZ-induced diabetic LDLR mice. PMID: 25714599
    16. Dual function of PPARgamma in CD11c+ cells ensures immune tolerance in the airways. PMID: 26062999
    17. CD11c-expressing B cells are located at the T cell/B cell border in spleen and are potent antigen-presenting cells. PMID: 26034175
    18. Our findings suggest that increased numbers of CD11c(+) macrophages and elevated levels of TNF-alpha and MMP-3 in AT and ST may explain the relationship between hyperlipidaemia and OA. PMID: 25693634
    19. Selective ablation of ICOSL in CD11c+ cells, but not in B cells, dramatically ameliorates kidney and lung inflammation in lupus-prone transgenic mice. PMID: 25786178
    20. the role of the aryl hydrocarbon receptor in the function of CD11c cells during respiratory viral infection. PMID: 24519489
    21. provide new insight into how CD11c(+) cells regulate the lymph node vascular-stromal compartment, add to the evolving understanding of functional stromal subsets PMID: 24659690
    22. Data indicate taht tumor necrosis factor receptor superfamily member 14 (TNFRSF14)participated in ovariectomy (OVX)-induced adipose tissue (AT) inflammation via upregulation of CD11c, resulting in metabolic perturbation. PMID: 24287621
    23. The findings identify CD11c macrophages in the lung are likely an important source of IL-23 during ALI, which may be helpful for better understanding of this disease. PMID: 23481504
    24. CD11c+ dendritic cells are essential for de novo induction of Foxp3 expression in naive CD4+ T cells and for airway tolerance. PMID: 23733880
    25. Approximately 26.6% of the cells in DC+ fraction co-expressed CD11c+ and F4/80 markers. PMID: 23146677
    26. Data conclude that both GM-CSF and FLT3L act through PU.1 to activate the 5.3 Kb CD11c proximal promoter in DCs and to induce differentiation of monocyte-derived DCs. PMID: 23284905
    27. down-regulated upon dendritic cell activation through Toll-like receptor triggering PMID: 22445076
    28. Data indicate the amounts of Ptpn6 (Shp1) and MyD88 protein were reduced in dendritic cells of Ptpn6fl/flMyd88fl/flItgax-cre mice. PMID: 23521885
    29. IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells PMID: 22815909
    30. AP-1 composed with JunD and Fra2 protein plays a primary role in enhancing the transcription level of the CD11c gene in dendritic cells PMID: 22990073
    31. CD11c+ cells produce cytokines and/or chemokines required for VCAM-1 upregulation on lung endothelium, which in turn is crucial for Cd11c+ induced mast cell progenitor recruitment and an increase in mast cell numbers. PMID: 22972929
    32. This study showed that, while CD11c(high) DCs initiate helminth-specific adaptive immunity, innate type 2 cells are able to mount an autonomous response to the challenge of parasite infection. PMID: 22851746
    33. airway epithelial NF-kappaB activation is a critical modulator of the adaptive immune response to inhaled antigens via soluble mediator secretion to affect the capacity of CD11c(+) cells to undergo maturation and promote antigen-specific allergic responses PMID: 20581095
    34. Residential macrophages require integrin alphaXbeta2 to control Candida albicans invasion of the brain in vivo. PMID: 22844116
    35. A model where CD23(+) B cells act as antigen transporting cells, delivering antigen to CD11c(+) cells for presentation to T cells is consistent with available experimental data. PMID: 21765910
    36. Our studies provide for the first time evidence that CD11c expression may abrogate the ability to reduce primary virus replication in the eye and TG via higher activities of type 1 interferon and CD8(+) T cell responses. PMID: 21775452
    37. Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis. PMID: 21436315
    38. Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209. PMID: 21427223
    39. Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury. PMID: 20388633
    40. Pulmonary CD11c+ cells are critical for NO2-promoted allergic sensitization via antigenspecifici CD4+ T-cell polarization. PMID: 20659336
    41. findings point to role for CR4 on dendritic cells in triggering B cells during humoral immunity PMID: 20465572
    42. CD11c-positive dendritic cells make a critical downstream contribution to anti-death receptor (DR)5 antitumor activity. PMID: 20505139
    43. CD11c-positive M1-like ATMs can exhibit phenotypic plasticity and that the polarization of these cells between inflammatory and non-inflammatory states is well correlated to the presence of absence of insulin resistance PMID: 20308074
    44. Dendritic cells expressing CD11c and class II major histocompatibility antigens promote high endothelial cell quiescence in vitro and, in vivo, mediate quiescence in expanded lymph nodes. PMID: 20231692
    45. These data demonstrate that CD11c(+) cells play a critical role in protecting the organs from systemic injury caused by a pulmonary endotoxin challenge. PMID: 19948830
    46. Diet-induced obesity increased CD11c in both adipose tissue and blood. PMID: 19910635
    47. CD11c is a useful marker for detection and isolation of pulmonary antiviral cytotoxic T cells following RSV infection. PMID: 16011799
    48. 4-1BB stimulation enhanced both primary and memory anti-herpesvirus-1 CD8+ T cell responses, which was mediated by a massive expansion of antigen-specific CD11c+CD8+ T cells PMID: 16524567
    49. CD11c+ dendritic cells-derived osteoclasts are capable of inducing bone loss after adoptive transfer in vivo PMID: 16920972
    50. Results indicate that expression of p150/95 is critical on both T cells as well as other leukocytes for the development of demyelinating disease and may represent a novel therapeutic target for multiple sclerosis. PMID: 17525267

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 數(shù)據(jù)庫鏈接：