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  4. Recombinant Human Alpha-2A adrenergic receptor (ADRA2A)-VLPs

Recombinant Human Alpha-2A adrenergic receptor (ADRA2A)-VLPs

In Stock
  • 中文名稱：
  • 貨號：
    CSB-MP001388HU
  • 規(guī)格：
  • 圖片：
    • CSB-MP001388HU is detected by Mouse anti-6*His monoclonal antibody.
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    Mammalian cell
  • 分子量：
    52.0 kDa
  • 表達區(qū)域：
    1-465aa
  • 氨基酸序列
    MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions)
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile  water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃.
    Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
  • 基因功能參考文獻：
    1. Rs1800544 polymorphism is associated with bone turnover markers level in Chinese elderly individuals with osteoporotic fractures, indicating the involvement of genetic variation of a2A-AR gene in bone metabolism. PMID: 30033441
    2. ADRA2A genetic variation contributes independently to the risk of GDM in Caucasian women. PMID: 28976299
    3. Results describe association of ADRA2A rs553668 with type 2 diabetes in a Mexican population. PMID: 29800730
    4. Significant group*genotype interactions were found for 3 ADRA2A variants revealing steeper delay discounting (DD) in cocaine users (but not controls) carrying the G-allele of rs1800544, the T-allele of rs521674 and the C-allele of rs602618. High ADRA2A mRNA expression levels were significantly associated with a reduced tendency to choose smaller more immediate rewards in cocaine users. PMID: 26549422
    5. The summary of this study, none of the examined variants reached the threshold for statistical significance after correction for multiple testing. The SNP rs1800544 in ADRA2A, revealed nominally significant association, but the direction of effect was the opposite to that reported in previous studies conducted in children and adolescents. PMID: 27091191
    6. The results of this study suggested that ADRA2A rs3750625 contributes to poststress musculoskeletal pain severity by modulating miR-34a regulation PMID: 27805929
    7. This study reveled that ADA2A are up regulate in peripheral blood mononuclear cells in patient with multiple sclerosis. PMID: 27609280
    8. Results show that ADRA2A genetic variants are associated with blood glucose and stress-induced hyperglycemia after acute myocardial infarction in Caucasians. PMID: 27131769
    9. These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs. PMID: 28438833
    10. ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer. PMID: 26563278
    11. The ADRA2A C-1291G and COMT Val158Met genotypes and sex interact in predicting detection and perception of emotional valence in facial expressions PMID: 26234518
    12. ADRA2a is associated with heart rate recovery after exercise. PMID: 26058836
    13. Study is in line with previous reports of an association between ADRA2A gene variants and general reaction time variability during response selection tasks PMID: 25978426
    14. Genetic association of ADRA2A single nucleotide polymorphism with metabolic syndrome and high level insulin among the Tatars PMID: 26410938
    15. The rs10885122G>T polymorphism of the ADRA2A gene was not associated with type 2 diabetes mellitus in Euro-Brazilians, and carriers of the T allele had lower body weight in the presence of type 2 diabetes mellitus. PMID: 25926111
    16. Common polymorphisms in the ADRA2A gene are not associated with orthostatic hypotension risk in Chinese. PMID: 26427149
    17. The alpha2a AR expression in breast cancer was associated with Her-2 status (P = 0.048) and a marginal significance was observed between alpha2a AR expression and estrogen receptor (P = 0.061). PMID: 24559182
    18. Study found evidence that DNA variation in the ADRA2A gene may be causally related to ADHD-like behaviors, in part through its influence on intra-individual variability PMID: 24166412
    19. The accuracy of prediction for breast cancer relapse based solely on the expression of ADRA2A gene is high. PMID: 25110082
    20. Results show that ADRA2A genotype was associated with clozapine-induced sialorrhea PMID: 25163438
    21. Common polymorphisms in ADRA2A do not affect plasma membrane trafficking. PMID: 24643471
    22. No significant association was observed between alpha2-adrenergic receptor gene C-1291G polymorphism and irritable bowel syndrome in Turkish population. PMID: 24623286
    23. The study data indicated that carriage of the ADRA2A rs1800544 GG genotype was associated with body mass index reduction in schizophrenia patients following switching of antipsychotics to aripiprazole and ziprasidone. PMID: 24424705
    24. The ADRA2A gene is associated with withdrawn behavior and reinforces the role of catecholaminergic genes in the heritability of withdrawn behavior. PMID: 23808549
    25. We identified the c.1138 C>A (p.Arg380Arg) silent substitution. We conclude that ADRA2A non-synonymous sequence variants do not cause ADHD in our sample population. PMID: 24178896
    26. Cultured Achilles tendon tenocyte proliferation is induced by ADRA2A stimulation and inhibited by an ADRA2A blocker. PMID: 22292987
    27. 6.3-kb alpha2A-AR variant is associated with increased platelet reactivity to epinephrine and has an additive effect along with CYP2C19*2 loss-of-function allele on P2Y12-mediated platelet responses in patients with stable angina on dual antiplatelet therapy PMID: 24723553
    28. The present investigation reports results from a meta-analysis of family-based studies that did not find a significant association between the MspI polymorphism of the ADRA2A gene and attention-deficit hyperactivity disorder. PMID: 23751900
    29. The results of this study postulated that ADRA2A would have effects on attentional performance and white-matter abnormalities, particularly in frontal regions. PMID: 24026714
    30. Analysis of schizophrenic's MTHFR*ADRA2A (C677T*C-1291G) interaction revealed significant association between ADRA2A CC+CG genotype in the MTHFR TC+TT carriers (p=0.008). PMID: 24522021
    31. ADRA2A genetic polymorphisms are mainly associated with obesity and possibly with T2D in a Swedish population. PMID: 23526671
    32. The results of this study suggest that DNA variants of both SLC6A2 and ADRA2A in the adrenergic neurotransmitter system might alter the response to atomoxetine. PMID: 23266789
    33. The AA genotype of rs553668 in ADRA2A might be a genetic risk factor that increases type 2 diabetes mellitus susceptibility. [Meta-analysis] PMID: 23462695
    34. Allelic association between schizophrenia and the ADRA2A rs1800544 polymorphism was found, but it did not survive correction for multiple testing. PMID: 22940547
    35. the ADRA2A polymorphism, rs553668, is associated with lean type 2 diabetes patients in a Chinese Han population. PMID: 23153004
    36. Impulsive personality is an important predictor of risky driving. In alpha(2A)-adrenoceptor gene (ADRA2A) G allele carriers, general traffic risk and speeding decreased in response to the intervention, unlike in subjects with the CC genotype. PMID: 22694918
    37. The ADRA2A and ADRA2C polymorphisms did not contribute to an increased risk of ischemic stroke or any pathophysiological subtype PMID: 22560155
    38. The mortality rate of chronic systolic heart failure patients carrying no alpha(2c)-adrenoceptor Del322-325 alleles was significantly higher (almost 2.5-fold) than that of HF patients carrying >/=1 allele. PMID: 23207081
    39. genetic polymorphisms in the adrenergic system may not play a major role in antipsychotic-induced weight gain; however, adrenergic 2A receptor gene showed a significant interaction with the monoamine oxidase A in weight gainers PMID: 21823169
    40. The small GTPase Rab26 regulates the Golgi to cell surface traffic of alpha(2)-adrenergic receptors, likely through a physical interaction. PMID: 23105096
    41. the rs553668 polymorphism is associated with glucose worsening in subjects without diabetes at baseline PMID: 22061269
    42. In young African Americans, the -1291C/G promoter polymorphism in the alpha(2A) -AR gene was associated with vascular reactivity to stress; vasoconstriction increased as a linear function of the number of copies of the variant G allele. PMID: 22091949
    43. ADRA2A is involved in pre- and post-synaptic inhibition of norepinephrine signalling. PMID: 21070505
    44. Inhibition of ADRA2A receptor selectively prevents memory decline without altering beta-amyloid plaque or astrocytosis. PMID: 20850464
    45. Results describe the association between the effect of alpha(2A)-Adrenergic Receptor (ADRA2A) C-1291G gene polymorphism in the promoter region of the candidate gene and clinical effects (sedative and haemodynamics effects) of dexmedetomidine. PMID: 21104443
    46. Multiple ADRA2A SNPs are associated with metabolic traits, blood pressure and type 2 diabetes risk. PMID: 21455730
    47. neonatal ADRB2 p.Arg16 homozygosity, but not nitric oxide synthase genotype, confers a protective effect against developing ephedrine-induced fetal acidemia PMID: 21613201
    48. The genetic variants in ADRA2A are associated with different blood pressure responses to the selective alpha 2-selective agonist dexmedetomidine. PMID: 21325151
    49. Antecedent hypoglycaemia did not affect beta(2)-adrenergic receptor sensitivity in healthy GlyGly participants. PMID: 21298412
    50. This study do not support a significant role for the ADRA2A gene in ADHD pharmacogenetics, at least among adult patients. PMID: 21103886

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2A sub-subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 281

    OMIM: 104210

    KEGG: hsa:150

    STRING: 9606.ENSP00000280155

    UniGene: Hs.249159