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  4. PPARD Antibody

PPARD Antibody

  • 中文名稱：
    PPARD兔多克隆抗體
  • 貨號：
    CSB-PA565092
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA565092(PPARD Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    FAAR antibody; MGC3931 antibody; NR1C2 antibody; NUC1 antibody; NUCI antibody; NUCII antibody; Nuclear hormone receptor 1 antibody; Nuclear receptor subfamily 1 group C member 2 antibody; Peroxisome proliferative activated receptor delta antibody; Peroxisome proliferator-activated receptor beta (PPAR-beta) antibody; Peroxisome proliferator-activated receptor beta antibody; Peroxisome proliferator-activated receptor delta antibody; PPAR beta antibody; PPAR-beta antibody; PPAR-delta antibody; PPARB antibody; ppard antibody; PPARD_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human PPARD
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
  • 基因功能參考文獻：
    1. Results suggest that peroxisome proliferator-activated receptor beta overexpression is not an inherent property of breast cancer cell lines, but it may play a role through activation of downstream genes (PPARbeta). PMID: 12009300
    2. 4 polymorphisms were found: -409C/T (promoter, +73C/T (exon 1), +255A/G (exon 3), & +294T/C (exon 4). An interaction with the PPAR alpha L162V polymorphism was also detected for several lipid parameters. PPARD plays a role in cholesterol metabolism. PMID: 12615676
    3. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. PMID: 12909723
    4. results implicate PPAR-delta in the regulation of intestinal adenoma growth PMID: 14758356
    5. Positive associations of PPAR-delta polymorphisms with fasting plasma glucose and BMI detected in nondiabetic control subjects PMID: 14988273
    6. gene regulation by PPARdelta in the uterine cells uniquely responds to SRC-2, N-CoR, SMRT, or RIP140, and these interactions may be operative during implantation when these cofactors are abundantly expressed. PMID: 15001550
    7. PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates triglyceride accumulation in keratinocytes. PMID: 15102088
    8. 11beta-HSD2 is an additional target for PPAR delta, which may regulate human placental function PMID: 15591138
    9. This study was performed to determine whether specific activation of PPARdelta has direct effects on insulin action in skeletal muscle. PMID: 15793256
    10. COX-2 immunopositivity was significantly associated with PPARbeta and PPARgamma immunoreactivity. Microvessel density was significantly higher among PPARbeta-immunoreactive squamous cell carcinomas. PMID: 15811118
    11. PPARdelta signaling pathways are interconnected at the level of cross-regulation of their respective transcription factor mRNA levels PMID: 15890193
    12. PPARdelta expression is up-regulated between the first and third trimester, indicating a role for this nuclear receptor in placental function PMID: 15979543
    13. PPARdelta + 294T/C gene polymorphism in subjects with metabolic syndrome may be involved in the occurrence of obesity and dyslipidemia. PMID: 16053787
    14. PPARdelta partially rescued prostate epithelial cells from growth inhibition and also dramatically inhibited sulindac sulfide-mediated p21WAF1/CIP1 upregulation. PMID: 16091736
    15. PPARdelta +294T/C polymorphism has no influence on plasma lipoprotein concentrations, body mass index or atherosclerotic disease either in healthy subjects or in patients with DM-2, both in males and females. PMID: 16285997
    16. Single nucleotide polymorphisms of PPARD primarily affected insulin sensitivity by modifying glucose uptake in skeletal muscle but not in adipose tissue. PMID: 16306381
    17. The expression of PPARdelta gene in rectal cancers is not statistically different from normal mucosa. PMID: 16361076
    18. Human platelets contain PPARbeta and that its selective activation inhibits platelet aggregation. PMID: 16368717
    19. Data describe the activated form of the peroxisome proliferator-activated receptor-beta/delta using a ligand binding domain model. PMID: 16387648
    20. This review concludes that PPAR delta has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. PMID: 16511591
    21. PGI2 protects endothelial cells from H2O2-induced apoptosis by inducing PPARdelta binding to 14-3-3alpha promoter, thereby upregulating 14-3-3alpha protein expression. PMID: 16645156
    22. data provide further evidence for an involvement of PPARdelta in the regulation of BMI. PMID: 16652134
    23. Skeletal muscle mRNA expression of PPAR delta increased in type 2 diabetic patients with an improved clinical profile following low-intensity exercise, but were unchanged in patients who did not show exercise-mediated improvements in clinical parameters. PMID: 16752430
    24. Single nucleotide polymorphisms in PPARD modify the conversion from glucose intolerance to type 2 diabetes. PMID: 16804087
    25. Therefore, these results indicate that induction of fatty acid oxidation with PPARbeta activators during short-term exposition is not sufficient to correct for insulin resistance in muscle cells from type 2 diabetic patients. PMID: 16897074
    26. PPARbeta/delta is a novel regulator of endothelial cell proliferation and angiogenesis through VEGF. PMID: 17068288
    27. PPARD-87T/C polymorphism is associated with higher fasting plasma glucose concentrations in both normal glucose tolerant and diabetic subjects, largely due to impaired insulin sensitivity PMID: 17116180
    28. PPAR-delta activation increases cholesterol export and represses inflammatory gene expression in macrophages and atherosclerotic lesions. PMID: 17119917
    29. support the rationale for developing PPARdelta antagonists for prevention and/or treatment of cancer PMID: 17148604
    30. These studies demonstrate that ligand activation of PPARbeta/delta does not lead to an anti-apoptotic effect in either human or mouse keratinocytes, but rather, leads to inhibition of cell growth likely through the induction of terminal differentiation. PMID: 17254750
    31. DNA sequence variation in the PPARdelta locus is a potential modifier of changes in cardiorespiratory fitness and plasma HDL-C in healthy individuals in response to regular exercise. PMID: 17259439
    32. Low PPARD expression is associated with Prostate Cancer Growth. PMID: 29187400
    33. Study demonstrates that oleanolic acid, as a natural product, can ameliorate the high glucose-triggered endothelial function by activating the nuclear receptor PPARdelta. PMID: 28067284
    34. PPARD rs7770619 is a novel candidate variant for impaired fasting glucose and type 2 diabetes and shows association with malondialdehyde levels. PMID: 29776318
    35. The negative responders for aerobic training are carriers of the PPARD rs2267668 G allele. The best responders to aerobic training are PPARD rs1053049 TT and rs2267668 AA. PMID: 29762540
    36. The current results suggest that A/A carriers of PPAR-delta SNP (rs2267668) may enjoy fewer beneficial effects of exercise-centered lifestyle intervention on anthropometric indices and blood measurements. PMID: 29494521
    37. Polymorphism of PPARD is associated with late onset of type 2 diabetes mellitus. PMID: 28292576
    38. findings suggest that PPARdelta conditions CLL cells to survive in harsh microenvironmental conditions by reducing oxidative stress and increasing metabolic efficiency. PMID: 28050012
    39. Here, theauthors describe a novel PPARbeta/delta-dependent molecular cascade involving TGFbeta1 and miR-21-3p, which is activated in the epidermis in response to UV exposure. PMID: 27250636
    40. findings identified previously unrecognized role of IP-PPARdelta signal transduction pathway in the production of sAPPalpha in cerebral microvasculature. PMID: 26661245
    41. the metabolic events, controlled by PPARs, occurring during neuronal precursor differentiation, the glucose and lipid metabolism was investigated. PMID: 27860527
    42. PPAR-delta activation prevents in-stent restenosis and stent thrombosis. PMID: 27283742
    43. findings identify LPCAT3 as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3. PMID: 27913621
    44. The minor allele of rs2016520 and rs9794 in PPAR-delta and interaction between rs2016520 and non-smoking were associated with decreased risk of CVD. PMID: 28287878
    45. a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population. PMID: 27530449
    46. Results indicate that PPARdelta-mediated downregulation of Nox4 modulates cellular redox status, which in turn plays a critical role in extracellular matrix homeostasis through ROS-dependent regulation of MMP-2 activity. PMID: 26403493
    47. The PPAR-beta role in neuroblastoma cell tumorigenesis and differentiation PMID: 27996177
    48. These observations candidate PPARs as new biomarkers of follicle competence opening new hypotheses on controlled ovarian stimulation effects on ovarian physiology. PMID: 26332656
    49. The PPAR delta role in neuroblastoma cell tumorigenesis and differentiation PMID: 27996177
    50. PPARdelta activation may be a potential risk of atherosclerosis through enhancing activity of SMS2 PMID: 27278004

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 組織特異性：
    Ubiquitous with maximal levels in placenta and skeletal muscle.
  • 數(shù)據庫鏈接：

    HGNC: 9235

    OMIM: 600409

    KEGG: hsa:5467

    STRING: 9606.ENSP00000310928

    UniGene: Hs.696032