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P2RX1 Antibody, Biotin conjugated

  • 中文名稱：
    P2RX1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA017319LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) P2RX1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ATP receptor antibody; H.sapiens mRNA for ATP receptor antibody; P2 RX1 antibody; P2rx1 antibody; P2RX1 protein antibody; P2RX1_HUMAN antibody; P2X purinoceptor 1 antibody; P2X receptor subunit 1 antibody; P2X1 antibody; P2X1 receptor antibody; Purinergic receptor antibody; Purinergic receptor P2X ligand gated ion channel 1 antibody; Purinergic receptor P2X1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human P2X purinoceptor 1 protein (54-175AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.
  • 基因功能參考文獻(xiàn)：
    1. Healthy human eosinophils express functional P2X1 receptors whose activation leads to eosinophil alphaMbeta2 integrin-dependent adhesion. P2X1 responses are constitutively reduced in asthmatic compared with healthy eosinophils, probably as the result of an increase in extracellular nucleotide concentration. PMID: 27183585
    2. the expression of P2X1 transcript and its splicing variant P2X1del in most human monocytes PMID: 27823931
    3. These data suggest that vascular smooth muscle cells from human gastro-omental arteries express P2X1 and P2X4 receptor subunits PMID: 24845338
    4. enhances platelet activation evoked by mild stimulants via the p38 signalling pathway PMID: 24633352
    5. In conclusion, our results demonstrate for the first time that adenine nucleotides acting at P2X1 receptors inhibit the proliferation of human coronary smooth muscle cells via the induction of the early gene NR4A1. PMID: 23873636
    6. With the development of leukemia, the expression of P2X7R increased in both bone marrow and spleen macrophages whereas expression of P2X1 Receptor increased in spleen macrophages. PMID: 24661878
    7. Increased P2X1 receptor expression and ATP release may have contributed to the augmentation of contractile response induced by hypoxia-glucopenia and reoxygenation in he detrusor muscles. PMID: 23975903
    8. Data indicate that MgATP2- activates P2X1 and P2X3, but not P2X2 and P2X4 receptors. PMID: 23959888
    9. the contribution of the extracellular, transmembrane, and intracellular segments to recovery from desensitization PMID: 23740251
    10. P2X(1) ion channels play a protective role in endotoxemia by negatively regulating systemic neutrophil activation, thereby limiting the oxidative response, coagulation, and organ damage. PMID: 22212928
    11. These results suggest that conformational change in the P2X1 receptor is required for co-ordination of ATP action. PMID: 22971236
    12. HSP90 inhibitors may be as effective as selective antagonists in regulating platelet P2X1 receptors, and their potential effects on hemostasis should be considered in clinical studies. PMID: 22851178
    13. Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel PMID: 22393010
    14. Studies indicate that P2X1, P2X2, and P2X4 receptors are detected in preglomerular microvessels. PMID: 21768526
    15. the cytoskeleton plays an important role in P2X1 receptor regulation PMID: 21757694
    16. Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating. PMID: 21690089
    17. T-cell receptor stimulation results in the translocation of P2X1 and P2X4 receptors and pannexin-1 hemichannels to the immune synapse. PMID: 20660288
    18. PMA-evoked Ca(2+)entry results from an NCX3-dependent dense granule secretion and subsequent P(2X1) receptor activation by secreted ATP, rather than activation of a novel NCCE pathway. PMID: 20345709
    19. Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP PMID: 20699225
    20. these studies demonstrate for the first time an important role of receptor recycling on P2X1 receptor responsiveness PMID: 20374431
    21. TLR2/1 agonist-induced platelet aggregation and secretion depends on a P2X1-mediated Ca2+ mobilisation, production of TxA2 and ADP receptor activation PMID: 20024498
    22. Studies indicate that release of ATP and the subsequent activation of P2 receptors help establish the basal level of activation for signal transduction pathways and regulate a wide array of responses. PMID: 20068232
    23. P2X(1) receptors showed an anti-inflammatory effect reducing NF-kappaB activation and TNF-alpha release. PMID: 20110693
    24. Expression is reduced in typ3 2 diabetes, not due to alterations in receptor distribution and mRNA expression, but may be due to differences in receptor sensitivity. PMID: 19808895
    25. Data confirmed the presence of functional P2X1, P2X4 and P2X7 receptors in LAD2 cells and HLMCs. PMID: 19552691
    26. Ionotropic P2X1 receptors may play a priming role in the subsequent activation of metabotropic P2Y receptors during platelet stimulation. PMID: 11815371
    27. P2X1 ion channel acts as a positive regulator of platelet responses to collagen. PMID: 11816716
    28. role of tyrosine residues essential for function PMID: 12135734
    29. Mediates activation of extracellular signal-regulated kinase 2 and contributes to platelet secretion and aggregation induced by collagen PMID: 12239162
    30. early, transient Ca2+ influx via P2X1 receptors can contribute to platelet activation by stimulating a significant morphological change, but does not readily synergise with P2Y12 receptors to support aggregation PMID: 12353081
    31. plays a role in hemostasis and thrombosis through its participation in collagen-, thromboxane A(2)-, and shear stress-triggered platelet responses PMID: 12521992
    32. Decreased expression of the contractile P2X1 receptor could lead to reduced vascular tonus and increased blood flow. PMID: 12791671
    33. ATP is the principal physiologic agonist at P2X1 receptors and it plays a role in the activation of platelets. PMID: 12907444
    34. the P2X1-ERK2-Myosin Light Chain Kinase axis contributes to collagen-induced platelet activation by enhancing platelet degranulation PMID: 14500714
    35. Detrusor nerve varicosities from sensory urgency patients revealed general loss of all presynaptic P2X subtypes with the proportion containing receptors reducing to only 0.5-5% depending on P2X subtype. PMID: 14557870
    36. P2X1 stimulation can induce/potentiate platelet activation in combination with other platelet agonists PMID: 14675100
    37. residues Lys-68, Phe-185, Phe-291, Arg-292, and Lys-309 contribute to ligand binding at P2X(1) receptors, with Phe-185 and Phe-291 coordinating the binding of the adenine ring of ATP PMID: 14699168
    38. the P2X(1) ion channel induces MLC-mediated cytoskeletal rearrangements, thus contributing to SIPA and degranulation during VWF-triggered platelet activation PMID: 15087444
    39. P2X1 receptors are expressed in human cardiomyocytes and mainly distributed in the regions of intercalated discs; there is some close association of P2X1 receptors and connexin43 in some, not all, regions. PMID: 15686781
    40. Results suggest that lipid rafts play an important role in P2X1 receptor-mediated control of arteries. PMID: 16006561
    41. P2X1 receptors have a role in the early collagen-evoked intracellular Ca2+ responses of human platelets PMID: 16113781
    42. glycine 250 substitution by serine gave functional responses to ATP with no effect on ATP sensitivity but a reduction in peak amplitude to P2X1 receptors PMID: 16236030
    43. P2X receptor-mediated contractions of human pregnant uterus to alpha,beta-meATP and EFS, but not to ATP, are increased with the progression of pregnancy PMID: 16359770
    44. P2X(1) and ERK2 both participate in shear stress controlled thrombosis, but ERK2 activation is initiated predominantly via GPIb-VWF interactions. PMID: 16420578
    45. identified and characterized the P2X1 promoter utilized in MEG-01 cells and showed that binding of Sp1/3 and NF-1 to elements in the direct vicinity of the transcription start site is essential for basal transcription PMID: 16529657
    46. We conclude that lipid rafts play a significant role in the regulation of P2X1 but not P2Y1 receptors in human platelets and that a reserve of non-functional P2X1 receptors may exist. PMID: 16546137
    47. analysis of a novel interaction between platelet P2X1 and thrombin receptors, with P2X1 functioning to amplify aggregation responses at low levels of thrombin receptor stimulation PMID: 16634759
    48. Co-expression of T18A and K367A mutant P2X1 receptors produced larger ATP evoked responses than either mutant alone and suggests that these amino and carboxy terminal regions interact to regulate channel function PMID: 16997281
    49. P2X1 mRNA expression may occur as a result of an increased component of neural ATP release in the aging bladder. PMID: 17399929
    50. PAR4-pretreated platelets, epinephrine caused dense granule secretion, and subsequent signaling from the ATP-gated P2X(1)-receptor and the alpha(2A)-adrenergic receptor induced aggregation. PMID: 18480058

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    P2X receptor family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8533

    OMIM: 600845

    KEGG: hsa:5023

    STRING: 9606.ENSP00000225538

    UniGene: Hs.41735