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KDM6A Antibody

  • 中文名稱：
    KDM6A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA025774LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • IHC image of CSB-PA025774LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KDM6A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX) antibody; bA386N14.2 antibody; bA386N14.2 ubiquitously transcribed X chromosome tetratricopeptide repeat protein UTX antibody; DKFZp686A03225 antibody; Histone demethylase UTX antibody; KABUK2 antibody; Kdm6a antibody; KDM6A_HUMAN antibody; Lysine (K) specific demethylase 6A antibody; Lysine K specific demethylase 6A antibody; Lysine specific demethylase 6A ubiquitously transcribed tetratricopeptide repeat gene X chromosome antibody; Lysine-specific demethylase 6A antibody; MGC141941 antibody; Ubiquitously transcribed tetratricopeptide repeat X chromosome antibody; Ubiquitously transcribed tetratricopeptide repeat protein X linked antibody; Ubiquitously transcribed TPR gene on the X chromosome antibody; Ubiquitously transcribed TPR protein on the X chromosome antibody; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein antibody; Ubiquitously-transcribed TPR protein on the X chromosome antibody; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein antibody; UTX antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Lysine-specific demethylase 6A protein (620-749AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，KDM6A Antibody (CSB-PA025774LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于KDM6A Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA025774LB01HU KDM6A Antibody, HRP conjugated ELISA
    FITC CSB-PA025774LC01HU KDM6A Antibody, FITC conjugated
    Biotin CSB-PA025774LD01HU KDM6A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.
  • 基因功能參考文獻(xiàn)：
    1. The histone demethylase UTX/KDM6A is mutated in up to 10% of cases of multiple myeloma, activating genes by removing the H3K27me3 repressive histone mark, counteracting EZH2 activity. PMID: 30166694
    2. Lymphomas with low UTX expression express high levels of Efnb1, and cause significantly poor survival. PMID: 30006524
    3. data suggest that haploinsufficiency for KDM6A due to mosaic X chromosome monosomy may be responsible for hyperinsulinism in Turner syndrome. PMID: 29902804
    4. High UTX expression is independently associated with a better prognosis in patients with esophageal squamous cell carcinoma (ESCC) and downregulation of UTX increases ESCC cell growth and decreases E-cadherin expression. Our results suggest that UTX may be a novel therapeutic target for patients with ESCC. PMID: 29351209
    5. Depletion of KDM6A inhibits the expression of SOX9, Col2a1, ACAN and results in increased H3K27me3 and decreased H3K4me3 levels. PMID: 29171124
    6. Rebalance of Histone h3 lysine 27 methylation 3 levels at specific genes through EZH2 inhibitors may be a therapeutic strategy in multiple myeloma cases harboring UTX mutations. PMID: 29045832
    7. both UTX and UTY function as dose-dependent suppressors of urothelial bladder cancer development PMID: 27533081
    8. Two novel missense mutations: p.G325A in the KDM6A gene responsible for Kabuki syndrome and p.G1877V in the SCN1A gene responsible for generalized epilepsy with febrile seizures plus were identified using the TruSight One sequencing panel. PMID: 28442529
    9. inactivating mutations of KDM6A, which are common in urothelial bladder carcinoma, are potentially targetable by inhibiting EZH2. PMID: 28228601
    10. Study presents a mutation screening of patients with Kabuki syndrome type 1 which identified 208 mutations in KMT2D. Two of the KDM6A mutations were maternally inherited and nine were shown to be de novo. PMID: 27302555
    11. Data show that more mutations in the histone lysine demethylase KDM6A were present in non-invasive tumors from females than males. PMID: 29136510
    12. Here, we discuss the roles of lysine 27 demethylases, JMJD3 and UTX, in cancer and potential therapeutic avenues targeting these enzymes. Despite a high degree of sequence similarity in the catalytic domain between JMJD3 and UTX, numerous studies revealed surprisingly contrasting roles in cellular reprogramming and cancer, particularly leukemia PMID: 27151432
    13. we identified a novel de novo deletion of KDM6A in a Chinese girl with KS. We consider her allergic skin manifestations to be part of the phenotypic spectrum of KS PMID: 27028180
    14. KDM6A and p21CIP1 expression are essential to curb E7 induced replication stress to levels that do not markedly interfere with cell viability PMID: 28968467
    15. Study identified a feed-forward loop between UTX and ER in the regulation of hormonally responsive breast carcinogenesis. PMID: 28534508
    16. Mutation in KDM6A gene is associated with cancer more frequently in males. PMID: 27869828
    17. Pathogenic variants in KMT2D resulting in protein truncation in 43% (6/14; of which 3 are novel) of all cases were detected, while analysis of KDM6A was negative. MLPA analysis was negative in all instances. PMID: 26841933
    18. Kdm6a and Kdm6b were found to be significantly overexpressed in Malignant pleural mesothelioma (MPM) at the mRNA level. However, tests examining if targeting therapeutically Kdm6a/b using a specific small molecule inhibitor was potentially useful for treating MPM, revealed that members of the Kdm6 family may not be suitable candidates for therapy PMID: 28197626
    19. The results define UTX as a bivalency-resolving histone modifier necessary for stem cell differentiation PMID: 26762983
    20. UTX gene expression in renal cell carcinoma and bladder cancer. PMID: 27983522
    21. Mutations of the epigenetic genes KMT2D and KDM6A cause dysregulation of certain developmental genes and account for the multiple congenital anomalies of the syndrome PMID: 26898171
    22. UTX positively regulates E-cadherin expression in colon cancer cells. PMID: 26819089
    23. UTX is a prominent tumour suppressor that functions as a negative regulator of EMT-induced Cancer Stem Cell-like properties by epigenetically repressing epithelial-mesenchymal transition -TFs. PMID: 26303947
    24. Kabuki syndrome may be caused by mutations in one of two histone methyltransferase genes: KMT2D and KDM6A. PMID: 26049589
    25. Our results provide further support for the similar roles of KMT2D and KDM6A in the etiology of KS by using a vertebrate model organism to provide direct evidence of their roles in the development of organs and tissues affected in KS patients. PMID: 25972376
    26. Turner Syndrome subjects, who are predisposed to chronic ear infections, had reduced UTX expression in immune cells and decreased circulating CD4(+) CXCR5(+) T cell frequency. PMID: 26431949
    27. A report of novel KDM6A mutations in patients with Kabuki syndrome. PMID: 24527667
    28. The KDM6A gene is a histone demethylase specific for histone H3 Lysin 27 and regulates gene transcription [35]. In approximately 24% of urothelial carcinoma, KDM6A is altered. PMID: 26138514
    29. This study is the first to identify frequent BAP1 and BRCA pathway alterations in bladder cancer, show TERT promoter alterations are independent of other bladder cancer gene alterations, and show KDM6A loss is a driver of the bladder cancer phenotype. PMID: 25225064
    30. One girl had a novel splice-site mutation in KDM6A. PMID: 24739679
    31. Mutations in KMT2D gene were identified in 10/16 (62%) of the patients, whereas none of the patients had KDM6A mutations. PMID: 25281733
    32. H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia PMID: 25320243
    33. results demonstrate that UTX is implicated in IL-4 mediated transcriptional activation of the ALOX15 gene PMID: 24465480
    34. Results show that UTX interacts with the retinoic acid receptor alpha (RARalpha) and this interaction is essential for proper differentiation of leukemic U937 cells in response to retinoic acid. PMID: 25071154
    35. Both Ezh2 and Kdm6a were shown to affect expression of master regulatory genes involved in adipogenesis and osteogenesis. PMID: 24123378
    36. High levels of UTX or MLL4 are associated with poor prognosis in patients with breast cancer. PMID: 24491801
    37. The identification of novel KDM6A mutations in patients with Kabuki syndrome. PMID: 23913813
    38. PBRM1, KDM6A, SETD2 and BAP1 were unmethylated in all tumor and normal specimens. PMID: 23644518
    39. KDM6A is overexpressed in breast cancer patients with an unfavorable prognosis (mortality at 1 year, p=8.65E-7). PMID: 23266085
    40. This study demonistrated that KDM6A mutations were most commonly identified in subgroups in medulloblastoma. PMID: 23184418
    41. UTX histone demethylase plays important functional role in epigenetic alteration of HOX clusters during retinoic acid-induced neural differentiation. PMID: 23527641
    42. KDM6A contributes to the activation of WNT3 and DKK1 at different differentiation stages when WNT3 and DKK1 are required for mesendoderm and definitive endoderm differentiation. PMID: 22907667
    43. UTX regulates stem cell migration and hematopoiesis. PMID: 23365460
    44. Microdeletions and microduplications have not been identified in the MLL2 and KDM6A genes of a large cohort of patients with Kabuki syndrome. PMID: 22840376
    45. UXT is a potential interactor of HBV Pol. PMID: 21515470
    46. PAN RNA interacts with demethylases JMJD3 and UTX, and the histone methyltransferase MLL2 PMID: 22589717
    47. identification of Utx as a novel mediator with distinct functions during the re-establishment of pluripotency and germ cell development PMID: 22801502
    48. demonstrate that UTX directly associates with the promoters of the Mll1, Runx1, and Scl genes and modulate their transcription by controlling H3K27me3 marks on respective promoter regions. PMID: 22306297
    49. This study identifies KDM6A mutations as another cause of Kabuki syndrome and highlights the growing role of histone methylases and histone demethylases in multiple-congenital-anomaly and intellectual-disability syndromes. PMID: 22197486
    50. H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERalpha ligand dependency PMID: 21841772

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  • 相關(guān)疾病：
    Kabuki syndrome 2 (KABUK2)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    UTX family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12637

    OMIM: 300128

    KEGG: hsa:7403

    STRING: 9606.ENSP00000367203

    UniGene: Hs.522616