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ABCC3 Antibody

  • 中文名稱：
    ABCC3兔多克隆抗體
  • 貨號：
    CSB-PA003281
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot analysis of HepG2 cells using MRP3 Polyclonal Antibody
    • Western Blot analysis of HELA K562 293 cells using MRP3 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ABCC3
  • 別名：
    ABC 31 antibody; ABC31 antibody; ABCC 3 antibody; ABCC3 antibody; ATP binding cassette sub family C (CFTR/MRP) member 3 antibody; ATP binding cassette sub family C member 3 antibody; ATP-binding cassette sub-family C member 3 antibody; Canalicular multispecific organic anion transporter 2 antibody; Canicular multispecific organic anion transporter antibody; CMOAT 2 antibody; CMOAT2 antibody; EST90757 antibody; MLP 2 antibody; MLP2 antibody; MOAT D antibody; MOAT-D antibody; MOATD antibody; MRP 3 antibody; MRP3_HUMAN antibody; Multi specific organic anion transporter D antibody; Multi-specific organic anion transporter D antibody; Multidrug resistance associated protein 3 antibody; Multidrug resistance associated protein antibody; Multidrug resistance-associated protein 3 antibody; Multispecific organic anion tranporter D antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MRP3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells.
  • 基因功能參考文獻：
    1. CGI may function as an enhancer of the transcription of ABCC3. PMID: 29437875
    2. Data suggest that inhibition of sirtuin 1 and sirtuin 2 in hepatocellular carcinoma cells (a) impairs cell survival and cell migration and (b) down-regulates expression of P-glycoprotein and MRP3 (ATP binding cassette subfamily C member 3). PMID: 29545174
    3. Data show that bladder cancer is associated with perturbed expression of MRP3 and BCRP. PMID: 28586062
    4. Histological subtype of epithelial ovarian cancer correlated with the expression of PgP, MRP1, and MRP3. The lowest level of Pgp and MRP1 expression was found in endometrioid ovarian cancers PMID: 27739315
    5. miR-148a-siRNA and rifampin inhibited estradiol upregulation of MRP3 expression. miR-148a may be involved in the estrogen induction in intrahepatic cholestasis of pregnancy via PXR signaling. MRP3 may be involved. PMID: 28575098
    6. ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children. PMID: 26810133
    7. PXR is a potential biomarker for predicting outcome and activates MRP3 transcription by directly binding to its promoter resulting in an increased L-OHP efflux capacity, and resistance to L-OHP or platinum drugs in CRC. PMID: 28356150
    8. This study highlights the importance of ABCC3 transporters in drug resistance to chemotherapy in the context of breast cancer. PMID: 27171227
    9. Wnt signaling regulates ABCC3 expression in colon cancer cells, with the ABCC3 locus being a target of the transcription factors TCF7L2 and beta-catenin. PMID: 27709738
    10. ABCC3 is an important oncoprotein involved in glycolysis and drug resistance PMID: 26733163
    11. This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma PMID: 26337276
    12. High MRP expression is associated with sorafenib resistance in hepatocellular carcinoma. PMID: 26769852
    13. ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response. PMID: 26107220
    14. Data suggest that hepatic expression of MRP3 is up-regulated and canalicular localization of MRP2 is altered in pediatric patients with advanced nonalcoholic steatohepatitis; these alterations may be involved in changes observed in drug metabolism. PMID: 25788542
    15. ABCC3 expression may serve as a marker for MDR and predictor for poor clinical outcome of NSCLC. PMID: 24176985
    16. A functional Nrf2 response element within the eighth intron of the ABCC3 gene. PMID: 25349122
    17. Renal function of MRP3 is related to renal cell proliferation and cyst formation and that restoring MRP3 may be an effective therapeutic approach for polycystic kidney disease. PMID: 25143454
    18. These results suggest that carboplatin and paclitaxel may induce drug resistance mediated by MDR1 and MRP3, which may be enhanced by the simultaneous use of both drugs. PMID: 23443122
    19. ABCC3 promoter methylation does not seem to exhibit any impact on maximum platelet aggregation and clopidogrel response at all PMID: 25985567
    20. Epidermal growth factor - mediated epithelial-mesenchymal transition induces ABCC3 mRNA in MDA-MB-468 breast cancer cells. The process is calcium dependant. PMID: 25666946
    21. Our data suggest that besides bodyweight, OCT1 and ABCC3 genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children PMID: 25155932
    22. for ABCC3 variants, little evidence, if any, was found for an association of drug response to genetic variants PMID: 25162314
    23. variants of ABCB1 rs128503, ABCC3 rs4148416, and GSTP1 rs1695 are associated with response to chemotherapy and survival of osteosarcoma patients PMID: 24996541
    24. Aberrant expression of MRP3 in rectal cancer confers chemo-radioresistance. PMID: 25088576
    25. ABCC3 rs4148416 TT polymorphism is associated with poor response to chemotherapy in bone tumors. PMID: 24083708
    26. our results suggest that fusion protein scFvM58-sTRAIL with specificity for MRP3 is a highly selective therapeutic agent and may provide an alternative therapy for human Glioblastoma multiforme . PMID: 24272336
    27. The ABCC3 -211C/T polymorphism seems not to be associated with altered antiplatelet effects and clinical outcomes in clopidogrel-treated patients. PMID: 23692149
    28. A predictive model combining variants in TPMT, ABCC3, and COMT with clinical variables significantly improved the prediction of hearing-loss development as compared with using clinical risk factors alone PMID: 23588304
    29. Induction of MRP3 expression by 17alpha-ethynylestradiol requires recruitment of estrogen receptor-alpha and activator protein-1. PMID: 23747343
    30. human cornea models possessed MRP3 and BCRP expression, whereas no functional expression was found in rabbit and porcine corneas. PMID: 23069916
    31. Stimulation of ATPase and substrate translocation show positive cooperativity. Maximal stimulation of ATPase activity is substrate independent. PMID: 23176825
    32. Increased MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas. PMID: 22767273
    33. MRP3 A-189 T polymorphism was associated with treatment responses in acute lymphoblastic leukemia , likely due to the change in MRP3 efflux. PMID: 21606946
    34. Anti-ABCC3 IgA and IgG were determined using an enzyme-linked immunosorbent assay (ELISA) approach. PMID: 22699933
    35. Amplification and overexpression of the ABCC3 gene is associated with primary breast cancer. PMID: 22585709
    36. up-regulation of hepatic MRP3/ABCC3 expression in human obstructive cholestasis is likely triggered by TNFalpha, mediated by activation of JNK/SAPK and SP1. PMID: 22105759
    37. Findings show that the gene expression of ATP-dependent efflux transporters MRP1, -3, -4, -5, and p-gp fluctuated during stem cell-derived retinal pigment epithelial cells (hESC-RPE) maturation. PMID: 22272278
    38. We demonstrate direct involvement between nuclear factor erythroid-2-related factor 2 and the MRP3 promoter, which leads to the up-regulation of the MRP3 gene. PMID: 22089114
    39. investigation of vectorial transport across enterocytes: Data from Caco-2 cell monolayers, models for intestinal absorption, suggest that MRP3 mediates fexofenadine/zwitterion efflux across basolateral membrane. PMID: 21780830
    40. study identified genetic polymorphisms of ABCC3 and evaluated their effects on ABCC3 expression and MRP3 function; 61 genetic variants were identified in three ethnic populations; of these variants 17 were novel PMID: 21512263
    41. effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy PMID: 22016816
    42. Low ABCC3 expression was associated with reduced event-free survival of neuroblastoma patients. PMID: 21799180
    43. Used a spin-labeled ATP analog, SL-ATP, to study nucleotide binding to highly purified human multidrug resistance protein 3, MRP3. PMID: 20563633
    44. Immunohistochemical evaluation of human gliomas to determine the localization of MRP3 antigen using scFvs M25 and M58 showed a dense cytoplasmic and membranous staining pattern PMID: 19937796
    45. MDR1, MRP2, MRP3 and MRP5 levels are decreased by tetramethylpyrazine in human hepatocellular carcinoma cells PMID: 19956884
    46. Expression of MRP3 can be induced by certain nonsteroidal anti-inflammatory drugs (e.g., indomethacin) in a reactive oxygen species-dependent but cyclooxygenase-2-independent manner. PMID: 11820781
    47. tissue distribution and induction in normal human tissues and in cholestasis PMID: 11850532
    48. possible role in the removal of bile acids from the liver in cholestasis PMID: 12220224
    49. down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated. PMID: 12628490
    50. MRP3 active transport of estradiol-17-beta-d-glucuronide and MRP3 ATPase characteristics in isolated, inside-out membrane vesicles PMID: 12704183

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  • 亞細胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 組織特異性：
    Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 54

    OMIM: 604323

    KEGG: hsa:8714

    STRING: 9606.ENSP00000285238

    UniGene: Hs.463421