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  4. Rat Kidney injury molecule 1,Kim-1 ELISA Kit

Rat Kidney injury molecule 1,Kim-1 ELISA Kit

  • 中文名稱：
    大鼠腎損傷分子1(Kim-1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E08808r
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
        腎臟損傷分子1（Kidney Injury Molecule-1，Kim-1）是一種被廣泛研究的生物標(biāo)志物，其主要存在于腎小管上皮細胞中。Kim-1的表達水平通常與腎臟損傷的嚴重程度相關(guān)，因此被廣泛用于腎臟損傷的診斷、預(yù)測和監(jiān)測。近年來，Kim-1的研究還拓展到肝臟、心血管和腫瘤等領(lǐng)域，其在多種疾病的發(fā)病機制中發(fā)揮重要作用。
        華美生物所提供的Rat Kidney injury molecule 1,Kim-1 ELISA Kit屬于ELISA檢測試劑盒，采用雙抗夾心法定量檢測大鼠血清、血漿、尿液樣本中的Kim-1，其靈敏度為0.228 ng/mL，檢測范圍為0.313 ng/mL-20 ng/mL。
     
  • 別名：
    Havcr1; Kim1; Hepatitis A virus cellular receptor 1 homolog; HAVcr-1; Kidney injury molecule 1; KIM-1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; CD antigen CD365
  • 縮寫：
    Kim-1
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, urine
  • 檢測范圍：
    0.313 ng/mL-20 ng/mL
  • 靈敏度：
    0.228 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of Rat Kim-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

  • 標(biāo)準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻

產(chǎn)品評價

靶點詳情

  • 最新研究進展：
    Kim-1是一種腎小管損傷標(biāo)志物，也稱為Timm-1，是由跨膜蛋白質(zhì)編碼的蛋白質(zhì)，其全稱為腎小管上皮細胞生長因子相關(guān)分子-1（Kidney injury molecule-1）。Kim-1的表達受腎小管損傷的調(diào)控，已被證明對于腎臟疾病的早期診斷和監(jiān)測有很大的幫助。
    最近的研究表明，Kim-1可能與腎臟外的許多其他疾病有關(guān)，例如心血管疾病、糖尿病和肝臟疾病。此外，一些研究還探討了Kim-1在腎移植領(lǐng)域中的應(yīng)用，包括在腎移植后的預(yù)后評估、排斥反應(yīng)的診斷和治療方案的制定中的作用。
  • 功能：
    May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair.
  • 基因功能參考文獻：
    1. High KIM1 expression is associated with decreased proximal tubular epithelial cell function. PMID: 29045706
    2. urinary KIM1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM1. PMID: 28075469
    3. Results show that in contrast to other known molecules indicating renal injury and/or repair mechanisms, the chronic renal expression of Kim-1 is strictly confined to proximal cysts. PMID: 27231899
    4. blood biomarker that specifically reflects acute and chronic kidney injury PMID: 24904085
    5. Ischemic postconditioning can attenuate the renal ischemia reperfusion injury and downregulate the expression of Kim-1. PMID: 22898836
    6. These studies are the first direct demonstration of regulation of KIM-1 in response to oxalate exposure in renal epithelial cells in vitro and in vivo. PMID: 22984472
    7. The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1. PMID: 21905055
    8. The Kim1 gene is regulated in an epigenetic fashion under conditions of nephrotoxicity. PMID: 20660082
    9. Results show Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. PMID: 20458318
    10. KIM-1 as a sensitive molecular marker of different levels of tubular injury PMID: 20305092
    11. Urinary Kim-1 serve as a noninvasive, rapid, sensitive, reproducible method to detect early kidney injury in pathophysiological studies and in preclinical drug development studies for risk-benefit profiling of pharmaceutical agents. PMID: 16174863
    12. These results implicate involvement of kidney injury molecule 1 (Kim-1) in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage. PMID: 16467126
    13. Kim-1 is associated with development of renin-angiotensin system-mediated renal damage PMID: 16896183
    14. Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury PMID: 17934191
    15. Data demonstrate that injured kidney epithelial cells assumed attributes of endogenous phagocytes, and that KIM-1 was directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and also porcine and canine epithelial cell lines. PMID: 18414680
    16. on longitudinal follow-up during antiproteinuric treatment increased renal Kim-1 expression is reversible in proportion to proteinuria reduction, likely reflecting reversibility of early tubular injury PMID: 19225054
    17. Cadmium-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule. PMID: 19371613
    18. Kim-1 is a sensitive biomarker of the early stages of Cadmium-induced proximal tubule injury. PMID: 19371616
    19. Dipsticks can provide a sensitive and accurate detection of Havcr1. PMID: 19387469
    20. Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage. PMID: 19522876

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, TIM family
  • 組織特異性：
    Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.
  • 數(shù)據(jù)庫鏈接：