Rat Interleukin 17,IL-17 ELISA KIT
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中文名稱:大鼠白介素17(IL-17)酶聯(lián)免疫試劑盒
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貨號:CSB-E07451r
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規(guī)格:96T/48T
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價格:¥3200/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:IL17A(Interleukin-17A),又稱為CTLAF-7 (Cytotoxic T-lymphocyte-associated factor 7)或者是IL-17,是一種細(xì)胞因子,由Th17淋巴細(xì)胞分泌,是一種免疫系統(tǒng)中的重要炎癥介質(zhì)。IL17A能夠吸引和活化中性粒細(xì)胞、T淋巴細(xì)胞和單核細(xì)胞,同時還能刺激某些組織細(xì)胞產(chǎn)生其他炎癥介質(zhì)。人體內(nèi)IL17A的含量與炎癥反應(yīng)及某些自身免疫性疾病的發(fā)生密切相關(guān)。華美生物所提供的Rat Interleukin 17,IL-17 ELISA KIT屬于ELISA檢測試劑盒,采用雙抗夾心法定量檢測大鼠血清、血漿、組織勻漿樣本中的IL17A,其靈敏度為23.43 pg/mL,檢測范圍為93.75 pg/mL-6000 pg/mL。
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別名:Il17a ELISA Kit; Ctla8 ELISA Kit; Il17Interleukin-17A ELISA Kit; IL-17 ELISA Kit; IL-17A ELISA Kit; Cytotoxic T-lymphocyte-associated antigen 8 ELISA Kit; CTLA-8 ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Rattus norvegicus (Rat)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:93.75 pg/mL-6000 pg/mL
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靈敏度:23.43 pg/mL
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Immunology
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of rat IL-17 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 87 Range % 80-95 1:2 Average % 85 Range % 80-95 1:4 Average % 90 Range % 86-100 1:8 Average % 92 Range % 86-97 -
回收率:
The recovery of rat IL-17 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 90 85-98 EDTA plasma (n=4) 93 88-101 -
標(biāo)準(zhǔn)曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. pg/ml OD1 OD2 Average Corrected 6000 1.865 1.802 1.834 1.739 3000 1.418 1.376 1.397 1.302 1500 1.036 1.004 1.020 0.925 750 0.624 0.589 0.607 0.512 375 0.379 0.364 0.372 0.277 187.5 0.211 0.209 0.210 0.115 93.75 0.132 0.122 0.127 0.032 0 0.099 0.091 0.095 -
數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg F Zhu,European journal of nutrition,2024
- Dietary fiber may benefit chondrocyte activity maintenance Y Wu,Frontiers in cellular and infection microbiology,2024
- Impact of humid climate on rheumatoid arthritis faecal microbiome and metabolites D Wang,Scientific reports,2023
- Chitosan-Low Molecular Weight Heparin Sodium Nanoparticles Regulate Treg/Th17 Immune Balance and Inflammation at the Maternal-Fetal Interface to Ameliorate Pre-Eclampsia by HB-EGF M Peng,Advanced Therapeutics,2023
- Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats J Zhang,Biomedicine & pharmacotherapy,2023
- Therapeutic Potential of Curcumin in a Rat Model of Dextran Sulfate Sodium–Induced Ulcerative Colitis by Regulating the Balance of Treg/Th17 Cells J Guo,Inflammation,2023
- Efficiency of Bone Marrow-Derived Mesenchymal Stem Cells and Hesperetin in the Treatment of Streptozotocin-Induced Type 1 Diabetes in Wistar Rats OM Ahmed,Pharmaceuticals,2023
- Sunitinib displays pulmonary fibrosis in experimental rats: Role of IL-17A dependent pathway ME Asker,International immunopharmacology,2023
- Imatinib mitigates experimentally-induced ulcerative colitis: Possible contribution of NF-kB/JAK2/STAT3/COX2 signaling pathway M Shalaby,Life sciences,2023
- Jinfeng pills ameliorate premature ovarian insufficiency induced by cyclophosphamide in rats and correlate to modulating IL-17A/IL-6 axis and MEK/ERK signals Y Hu,Journal of ethnopharmacology,2023
- Diosmin and Trolox Have Anti-Arthritic, Anti-Inflammatory and Antioxidant Potencies in Complete Freund’s Adjuvant-Induced Arthritic Male Wistar Rats: Roles of NF-κB, iNOS, Nrf2 and MMPs HH Shaaban,Antioxidants,2022
- Study on the Mechanism of Bu-Shen-He-Mai Granules in Improving Renal Damage of Ageing Spontaneously Hypertensive Rats by Regulating Th17 Cell/Tregs Balance P Zhang,Evidence-based complementary and alternative medicine,2022
- The mechanism of a humid climate on the joints of normal rats and collagen-induced arthritis rats: mutual effects on faecal metabolism and microbial diversity D Wang,ResearchSquare,2022
- IL-17 is a Potential Therapeutic Target in a Rodent Model of Otitis Media with Effusion N Zhang,Journal of Inflammation Research,2022
- Mesenchymal stem cells moderate experimental autoimmune uveitis by dynamic regulating Th17 and Breg cells response Yajun Mu,Journal of Tissue Engineering and Regenerative Medicine,2021
- SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats W Huang,Stem Cell Research & Therapy,2021
- Lycopene Modulates Placental Health and Fetal Development Under High‐Fat Diet During Pregnancy of Rats S Sun,Molecular Nutrition & Food Research,2021
- Inhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival A Ren,Journal of Inflammation Research,2021
- Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial?mesenchymal transition in the valvular damage due to rheumatic heart disease S Xian,Molecular Medicine Reports,2020
- Integration Traditional Chinese Medicine and Nibble Debridement and Dressing Method Reduce Thrombosis and Inammatory J Li,Research Square,2020
- Intervening in the S1PR1/STAT3 Signaling Pathway Attenuates Valvular Damage Due to Rheumatic Heart Disease S Xian,Research Square,2020
- The Protective Effect of Low Dose of Lipopolysaccharide Pretreatment on Endotoxin-Induced Uveitis in Rats Is Associated with Downregulation of CSF-1 and Upregulation of LRR-1 Y Ling,Journal of Immunology Research,2020
- Alagebrium Mitigates Metabolic Insults in High Carbohydrate and High Fat Diet Fed Wistar Rats S Hassan,Pharmaceutical Sciences,2020
- Inhibition of miR-155-5p attenuates the valvular damage induced by rheumatic heart disease Chen A, et al,International Journal of Molecular Medicine,2019
- Alagebrium Mitigates Metabolic Insults in High Carbohydrate High Fat Diet Fed Rats Hady S H A, et al,Pharmaceutical Sciences,2019
- Rapamycin attenuates Tc1 and Tc17 cell responses in cigarette smoke-induced emphysema in mice Zhang H, et al,Inflammation Research,2019
- Protective effect of methylene blue on TNBS-induced colitis in rats mediated through the modulation of inflammatory and apoptotic signalling pathways El Sayed NS, et al,Archives of Toxicology,2019
- Prednisone may rebuild the immunologic homeostasis: Alteration of Th17 and Treg cells in the lymphocytes from rats' spleens after treated with prednisone-\containing serum Fu XQ,MOLECULAR GENETICS & GENOMIC MEDICINE,2019
- Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis Kamel KM, et al,Life Sciences,2019
- Immunosuppressive effect of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via regulating the differentiation of CD4+ T cell subsets in rats Bai L, et al,International immunopharmacology,2019
- Methotrexate improves the anti-arthritic effects of Paeoniflorin-6'-O-benzene sulfonate by enhancing its pharmacokinetic properties in adjuvant-induced arthritis rats Asenso J, et al,Biomedicine & Pharmacotherapy,2019
- Novel Anti-arthritic Mechanisms of Polydatin in Complete Freund’s Adjuvant-Induced Arthritis in Rats: Involvement of IL-6, STAT-3, IL-17, and NF-кB Kamel M. Kamel.et al,Inflammation,2018
- Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats YuLong.et al,Biomedicine & Pharmacotherapy,2018
- Liuweibuqi capsules suppress inflammation by affecting T cell polarization and survival in chronic obstructive pulmonary disease Chengyang Wang.et al,Medicinal Chemistry Research,2017
- Maternal Carbamazepine Alters Fetal Neuroendocrine-cytokines Axis Ahmed RG.et al,Toxicology. ,2017
- Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile Masayuki Ito.et al,BMC Pulmonary Medicine,2017
- Synthetic p55 tandem DNA vaccine against Pneumocystis carinii in rats. Fan H.et al,Microbiol Immunol.,2016
- Matrine improves cognitive impairment and modulates the balance of Th17/Treg cytokines in a rat model of A尾1-42-induced Alzheimer's disease Zhang Y.et al,Cent Eur J Immunol.,2016
- Effect of Moderate Exercise on Serum Interferon-Gamma and Interleukin-17 Levels in the Morphine Withdrawal Period Ali Heidarianpour. et al,International Journal of High Risk Behaviors and Addiction,2016
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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最新研究進(jìn)展:IL17A是一種介導(dǎo)炎癥反應(yīng)的細(xì)胞因子,在自身免疫疾病和腫瘤等多種疾病中發(fā)揮重要作用。最新的研究表明,IL17A在肺癌中的作用十分復(fù)雜,可能具有促進(jìn)或抑制腫瘤發(fā)展的雙重作用。此外,研究人員還發(fā)現(xiàn),通過靶向IL17A和其受體可以增強(qiáng)腫瘤免疫應(yīng)答和抑制腫瘤的生長和轉(zhuǎn)移,為腫瘤治療提供了新的方向。
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功能:Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release. In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Involved in antiviral host defense through various mechanisms.
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亞細(xì)胞定位:Secreted.
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蛋白家族:IL-17 family
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數(shù)據(jù)庫鏈接:
STRING: 10116.ENSRNOP00000016664
UniGene: Rn.218513
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