Mouse CD9 antigen(CD9) ELISA kit

Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Acts as a receptor for PSG17. Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung.

1. The Cd9(-/-) and Cd9(-/-) Cd81(-/-) deletions are associated with a decreased microvilli density on the MII oocyte surface. Microvilli thickness is significantly increased whatever the deleted tetraspanin gene be. Only Cd9 deletion clearly disturbs the vesicular traffic, increasing the number of clathrin and exosome vesicles. PMID: 27879451
2. CD9 regulates the T cell-stimulatory capacity of granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent bone marrow-derived Dendritic Cells (BMDCs), without affecting antigen presentation by fms-like tyrosine kinase 3 ligand (Flt3L)-dependent BMDCs. PMID: 28533221
3. DPP4:CD9:TTSP as the protein complexes are necessary for early efficient MERS-coronavirus entry. PMID: 28759649
4. Our results indicate that the suppression of cartilage degradation in CD9(-/-) could be in part related to an increase in the expression of the two main cartilage extracellular matrix proteins aggrecan and type II collagen. PMID: 27784871
5. upregulation may play an important role in podocyte morphology, adhesion, and migration PMID: 25503725
6. Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties. PMID: 25564652
7. Data indicate that anti-inflammatory effects of statins are CD9-dependent. PMID: 24040034
8. study demonstrates ablation of Cd9 had no detectable effect on de novo primary proatate tumour onset, but did significantly increase metastasis to the liver but not the lungs PMID: 23575960
9. chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family PMID: 23443658
10. tetraspanin CD9 modulates molecular organization of integrins in lymphatic endothelial cells, thereby supporting several functions required for lymphangiogenesis PMID: 23223239
11. Tetraspanin family member CD9 plays an important role in sperm-egg fusion. PMID: 22609062
12. Results show that SSCs are the most concentrated in CD9(+)EPCAM(low/-) population and also suggest that EPCAM plays an important role in progenitor cell amplification in the mouse spermatogenic system. PMID: 21858196
13. Our study demonstrated the importance of CD9 in wound re-epithelialization, linking this molecule directly to basement membrane formation and epidermal migration through participating in the regulation of the JNK/MMP-9 pathway. PMID: 21881583
14. propose that sperm-egg fusion is a direct consequence of CD9 controlled sperm-egg adhesion properties. CD9 generates adhesion sites responsible for the strongest of the observed gamete interaction. PMID: 21690351
15. knockout mice display abnormal adult angiogenesis PMID: 20592186
16. This study characterizes CD9 in sperm development and fertilization. PMID: 20428892
17. Data show that B16F1 lones stably overexpressing CD9 had reduced ability to form colonies in soft agar PMID: 19777564
18. CD9 is identified as the first receptor for a murine PSG /glycoprotein 17/ PMID: 11805154
19. role of CD9 in the strengthening of fertilin beta-mediated cell adhesion PMID: 11906941
20. CD9 may play a role in LIF-mediated maintenance of undifferentiated ES cells. PMID: 11950938
21. CD9 down-regulation may be a sensitive indicator of macrophage differentiation PMID: 12056820
22. CD9 inhibits SMC migration by a stimulation of both stress fiber formation and integrin clustering, leading to a stimulation of FAK phosphorylation. PMID: 12083484
23. the function of CD9 in sperm-egg fusion is was analyzed in CD9-deficient mouse eggs PMID: 12086470
24. CD9 was enriched in myelinating oligodendrocytes and myelin internodes. Immunoprecipitation of CD9 from postnatal rat cerebrum coprecipitated beta1 integrin, CD81, and Tspan-2. PMID: 12420314
25. CD9 is found with with the alpha6beta1 integrin heterodimer in parietal endoderm cells , suggesting a role for CD9 in alpha6beta1 mediated migration of parietal endoderm. PMID: 12745436
26. CD9 is localized to paranodes and has a role in regulating paranodal junctional formation. PMID: 14715942
27. CD9 is dispensable for B cell development and humoral immunity. PMID: 16116178
28. During oogenesis the development of the ability of the oolemma to fuse with sperm may be regulated by synthesis of CD9 by the oocyte. PMID: 16719947
29. Taken together, these results suggest that CD9 expressed on osteoclast lineage cells might positively regulate osteoclastogenesis via the regulation of p44/42 MAPK activity. PMID: 16808899
30. CD9 expression by multiple myeloma cells is upregulated in vivo by close interaction of the cells with endothelial cells and CD9 is involved in transendothelial invasion PMID: 16900214
31. CD9 was differentially expressed in uterus depending on the stage of implantation & was upregulated in ovarian steroid hormone-dependent manner, implicating multiple roles of CD9 in regulation of embryo implantation during the peri-implantation period. PMID: 17126340
32. Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution. PMID: 17239847
33. The expression levels of both CD9 mRNA and protein in the frozen oocytes were significantly lower than those found in the fresh oocytes. PMID: 17307168
34. establish for the first time a role for CD9 in the tumorigenic process PMID: 17582603
35. The fusion-facilitating activity of CD9-containing vesicles by examining the fusion of sperm to CD9(-/-) eggs with the aid of exogenous CD9-containing vesicles, is investigated. PMID: 18728192
36. Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction. PMID: 19210920
37. macrophage CD9 negatively regulates LPS response at lipid-enriched membrane microdomains PMID: 19414803

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Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Secreted, extracellular exosome.

Tetraspanin (TM4SF) family

Expressed predominantly in the peripheral nervous system. Highly expressed in oocytes and blastocysts (at protein level). Expression is also observed on follicular oocytes in the ovary, whereas no expression is found on follicular cells (at protein level)

KEGG: mmu:12527

STRING: 10090.ENSMUSP00000032492

UniGene: Mm.210676