Mouse C-Reactive Protein,CRP ELISA Kit
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中文名稱:小鼠C反應(yīng)蛋白(CRP)酶聯(lián)免疫試劑盒
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貨號:CSB-E07923m(1)
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規(guī)格:96T/48T
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價格:¥3800/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:CRP (C-reactive protein) 是一種血漿蛋白質(zhì),由肝臟合成。在炎癥、組織損傷和感染等情況下,CRP的含量會顯著增加。CRP是一種炎癥標(biāo)志物,可以用于評估機(jī)體炎癥反應(yīng)的強度和嚴(yán)重程度,也可以用于監(jiān)測疾病治療效果。華美生物所提供的Mouse C-Reactive Protein,CRP ELISA Kit屬于ELISA檢測試劑盒,采用雙抗夾心法定量檢測鼠血清、血漿、組織勻漿樣本中的CRP,其靈敏度為5 ng/mL,檢測范圍為5 ng/mL-4000 ng/mL。
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別名:Crp ELISA Kit; Ptx1C-reactive protein ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:5 ng/mL-4000 ng/mL
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靈敏度:5 ng/mL
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Immunology
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測定原理:quantitative
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測定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
相關(guān)產(chǎn)品
靶點詳情
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最新研究進(jìn)展:C反應(yīng)蛋白(CRP)是一種急性相蛋白,可被廣泛應(yīng)用于臨床診斷、治療和預(yù)后。最近的研究表明,CRP不僅僅是炎癥的標(biāo)志物,它還可以直接調(diào)節(jié)免疫細(xì)胞的活動,例如刺激單核細(xì)胞的化學(xué)吸引和激活T細(xì)胞等。此外,一些研究還發(fā)現(xiàn)CRP可能與肥胖、代謝綜合征、心血管疾病等相關(guān)聯(lián)。
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功能:Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
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基因功能參考文獻(xiàn):
- CRP is pathogenic in type-2 diabetes (T2DN). CRP may promote CD32b- NF-kappaB signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling. PMID: 27221338
- FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation. PMID: 28539825
- C-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex. PMID: 27470679
- These results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK and NFkappaB signaling pathways. PMID: 27512978
- these data unexpectedly identify CBS as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP. PMID: 26907682
- CRP decreased adiponectin expression and multimerization, while CRP-induced decline in adiponectin might be mediated through the PI3K/Akt pathway. PMID: 26812237
- mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia. PMID: 26335098
- Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells PMID: 26328491
- These data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll-like receptor signaling pathways. PMID: 26687448
- Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
- the acute phase protein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by phagocytes in vivo PMID: 25548320
- CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors. PMID: 25088786
- Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH. PMID: 24466039
- The interactions of CRP and the BBB are a two-phase process, with increased paracellular permeability at a high dose that enables its entry into the CNS and serves to induce reactive gliosis and impair CNS function. PMID: 23018453
- In mice with photochemically induced thrombosis, acrolein produced at the locus of infarction increased the level of IL-6 and then CRP in plasma. PMID: 23763486
- CRP directly inhibits tumoral lymphangiogenesis and lymph node metastasis in mice. PMID: 23859309
- Which processes in glucose homeostasis are altered by CRP? Data suggest that CRP attenuates insulin-induced skeletal muscle blood flow; CRP contributes to insulin resistance via IgG receptor IIB-mediated inhibition of glucose delivery to muscle. PMID: 23069625
- CRP is not only a biomarker, but also a mediator in DKD. PMID: 21744073
- C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice. PMID: 21383672
- These findings reveal a novel nutrient-dependent interaction between Sirt1 and HNF-1alpha which results in regulation of Crp expression. PMID: 21176092
- Studies show that CRP itself may have a pathogenic role in the development of pressure overload-induced cardiac remodeling, possibly through enhanced inflammation and oxidative stress. PMID: 21220701
- No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice. PMID: 21149301
- Modified and natural C-reactive protein have opposite effects on atherosclerosis in apolipoprotein E-deficient mice. PMID: 16087790
- the contribution of CRP's ability of activating the classical pathway of complement in the protection of mice from lethal infection with virulent Streptococcus pneumoniae type 3 PMID: 16547275
- nCRP can facilitate cardiovascular disease through impairment of endothelium-dependent vasoreactivity, in a manner that involves increased iNOS activity and a potential for increased peroxynitrite formation. PMID: 17669410
- the response to vascular injury provoked by human C-Reactive Protein in ovariectomized C-reactive protein transgenic mice depends on Fc gamma RI and probably requires its expression by F4/80+ cells PMID: 18063701
- In vivo analyses revealed significant increases in TF expression and decreases in TFPI expression in carotid arteries of CRP-Tg mice versus WT mice. PMID: 18276908
- CRP plays a crucial role in the induction, amplification, and prolongation of inflammatory processes, including atherosclerotic lesions PMID: 18402807
- C-reactive protein has a role in impaired endothelial function PMID: 18433756
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亞細(xì)胞定位:Secreted.
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蛋白家族:Pentraxin family
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組織特異性:Found in plasma.
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